Tolerogenic Vaccines for Multiple Sclerosis

Overview

Journal Hum Vaccin Immunother

Specialty Allergy & Immunology

Date 2013 Jan 30

PMID 23357858

Citations 14

Authors

Mark D Mannie

Alan D Curtis 2nd

Affiliations

Soon will be listed here.

Abstract

Tolerogenic vaccines represent a new class of vaccine designed to re-establish immunological tolerance, restore immune homeostasis, and thereby reverse autoimmune disease. Tolerogenic vaccines induce long-term, antigen-specific, inhibitory memory that blocks pathogenic T cell responses via loss of effector T cells and gain of regulatory T cell function. Substantial advances have been realized in the generation of tolerogenic vaccines that inhibit experimental autoimmune encephalomyelitis in a preclinical setting, and these vaccines may be a prequel of the tolerogenic vaccines that may have therapeutic benefit in Multiple Sclerosis. The purpose here is to provide a snapshot of the current concepts and future prospects of tolerogenic vaccination for Multiple Sclerosis, along with the central challenges to clinical application.

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