» Articles » PMID: 23353755

Synthesis, Characterization and in Vitro Anticancer Evaluation of Novel 1,2,4-triazolin-3-one Derivatives

Overview
Journal Eur J Med Chem
Specialty Chemistry
Date 2013 Jan 29
PMID 23353755
Citations 4
Authors
Affiliations
Soon will be listed here.
Abstract

A series of novel 2-(4-chlorophenyl)-5-methyl-4-(2-amine/oxy-ethyl)-2,4-dihydro-[1,2,4]triazol-3-one (5a-t) were synthesized and in vitro anticancerous action of the resulting compounds was studied against NCI-60 Human Tumor Cell Line at a single high dose (10(-5) M) concentration for primary cytotoxicity assay. Among the tested compounds (5a-e, 5g-h, 5k, 5p), the compound 5g (NSC: 761736/1) was further evaluated for five dose criteria at five different minimal concentrations against the full panel of 60 human tumor cell lines which exhibited activity against Leukemia (GI50: 1.10 μM), Non-Small Cell Lung Cancer (GI50: 1.00 μM), Renal Cancer (GI50: 1.00 μM), Colon Cancer (GI50: 1.66 μM), CNS Cancer (GI50: 1.36 μM), Melanoma (GI50: 1.82 μM), Ovarian Cancer (GI50: 1.64 μM) and Breast Cancer (GI50: 1.69 μM).

Citing Articles

Ligand substituent effect on the cytotoxicity activity of two new copper(ii) complexes bearing 8-hydroxyquinoline derivatives: validated by MTT assay and apoptosis in MCF-7 cancer cell line (human breast cancer).

Ali A, Banerjee S, Kamaal S, Usman M, Das N, Afzal M RSC Adv. 2022; 11(24):14362-14373.

PMID: 35423979 PMC: 8697721. DOI: 10.1039/d1ra00172h.


Coumarins and Coumarin-Related Compounds in Pharmacotherapy of Cancer.

Akkol E, Genc Y, Karpuz B, Sobarzo-Sanchez E, Capasso R Cancers (Basel). 2020; 12(7).

PMID: 32707666 PMC: 7409047. DOI: 10.3390/cancers12071959.


Serendipitous Formation of 2-Pyrazolo[3,4-]pyridazin-7(6)-ones from 3-Arylsydnones.

Kumbar M, Shaikh S, Kamble R, Bayannavar P, Kamble A, Hunnur R ACS Omega. 2019; 4(3):4955-4962.

PMID: 31459679 PMC: 6647958. DOI: 10.1021/acsomega.8b02013.


The Role of Compounds Derived from Natural Supplement as Anticancer Agents in Renal Cell Carcinoma: A Review.

Haque I, Subramanian A, Huang C, Godwin A, Van Veldhuizen P, Banerjee S Int J Mol Sci. 2018; 19(1).

PMID: 29301217 PMC: 5796057. DOI: 10.3390/ijms19010107.