Incidence of End-stage Renal Disease in the Turkish-Cypriot Population of Northern Cyprus: a Population Based Study

Overview

Journal PLoS One

Specialties General Medicine
Science

Date 2013 Jan 26

PMID 23349874

Citations 6

Authors

Thomas M F Connor

D Deren Oygar

Daniel P Gale

Retha Steenkamp

Dorothea Nitsch

Guy H Neild

Patrick H Maxwell

Affiliations

Soon will be listed here.

Abstract

Background: This is the first report of the incidence and causes of end-stage renal disease (ESRD) of the Turkish-Cypriot population in Northern Cyprus.

Methods: Data were collected over eight consecutive years (2004-2011) from all those starting renal replacement therapy (RRT) in this population. Crude and age-standardised incidence at 90 days was calculated and comparisons made with other national registries. We collected DNA from the entire prevalent population. As an initial experiment we looked for two genetic causes of ESRD that have been reported in Greek Cypriots.

Results: Crude and age-standardised incidence at 90 days was 234 and 327 per million population (pmp) per year, respectively. The mean age was 63, and 62% were male. The age-adjusted prevalence of RRT in Turkish-Cypriots was 1543 pmp on 01/01/2011. The incidence of RRT is higher than other countries reporting to the European Renal Association - European Dialysis and Transplant Association, with the exception of Turkey. Diabetes is a major cause of ESRD in those under 65, accounting for 36% of incident cases followed by 30% with uncertain aetiology. 18% of the incident population had a family history of ESRD. We identified two families with thin basement membrane nephropathy caused by a mutation in COL4A3, but no new cases of CFHR5 nephropathy.

Conclusions: This study provides the first estimate of RRT incidence in the Turkish-Cypriot population, describes the contribution of different underlying diagnoses to ESRD, and provides a basis for healthcare policy planning.

Citing Articles

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Prevalence of Mediterranean FeVer Gene Mutations in Turkish Cypriot Population.

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Reporting renal biopsies from Cyprus: a systematic approach.

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A novel COL4A1 frameshift mutation in familial kidney disease: the importance of the C-terminal NC1 domain of type IV collagen.

Gale D, Oygar D, Lin F, Derin Oygar P, Khan N, Connor T Nephrol Dial Transplant. 2016; 31(11):1908-1914.

PMID: 27190376 PMC: 5091614. DOI: 10.1093/ndt/gfw051.

References

Loizou T, Pouloukas S, Tountas C, Thanopoulou A, Karamanos V . An epidemiologic study on the prevalence of diabetes, glucose intolerance, and metabolic syndrome in the adult population of the Republic of Cyprus. Diabetes Care. 2006; 29(7):1714-5. DOI: 10.2337/dc06-0696. View

Rosansky S, Clark W, Eggers P, Glassock R . Initiation of dialysis at higher GFRs: is the apparent rising tide of early dialysis harmful or helpful?. Kidney Int. 2009; 76(3):257-61. DOI: 10.1038/ki.2009.161. View

Voskarides K, Damianou L, Neocleous V, Zouvani I, Christodoulidou S, Hadjiconstantinou V . COL4A3/COL4A4 mutations producing focal segmental glomerulosclerosis and renal failure in thin basement membrane nephropathy. J Am Soc Nephrol. 2007; 18(11):3004-16. DOI: 10.1681/ASN.2007040444. View

Boddana P, Caskey F, Casula A, Ansell D . UK Renal Registry 11th Annual Report (December 2008): Chapter 14 UK Renal Registry and international comparisons. Nephron Clin Pract. 2009; 111 Suppl 1:c269-76. DOI: 10.1159/000210003. View

Caskey F, Kramer A, Elliott R, Stel V, Covic A, Cusumano A . Global variation in renal replacement therapy for end-stage renal disease. Nephrol Dial Transplant. 2011; 26(8):2604-10. DOI: 10.1093/ndt/gfq781. View

van Dijk P, Zwinderman A, Dekker F, Schon S, Stel V, Finne P . Effect of general population mortality on the north-south mortality gradient in patients on replacement therapy in Europe. Kidney Int. 2006; 71(1):53-9. DOI: 10.1038/sj.ki.5002008. View

Neild G, Oygar D, Ben Hmida M . Can we improve the diagnosis of renal failure? A revised coding system for the Middle East and North Africa. Saudi J Kidney Dis Transpl. 2011; 22(4):651-61. View

Baysal E, Indrak K, Bozkurt G, Berkalp A, Aritkan E, Old J . The beta-thalassaemia mutations in the population of Cyprus. Br J Haematol. 1992; 81(4):607-9. DOI: 10.1111/j.1365-2141.1992.tb03000.x. View

Freedman B, Volkova N, Satko S, Krisher J, Jurkovitz C, Soucie J . Population-based screening for family history of end-stage renal disease among incident dialysis patients. Am J Nephrol. 2005; 25(6):529-35. DOI: 10.1159/000088491. View

10.

Mochizuki T, Wu G, Hayashi T, Xenophontos S, Veldhuisen B, Saris J . PKD2, a gene for polycystic kidney disease that encodes an integral membrane protein. Science. 1996; 272(5266):1339-42. DOI: 10.1126/science.272.5266.1339. View

11.

Neild G . What do we know about chronic renal failure in young adults? I. Primary renal disease. Pediatr Nephrol. 2009; 24(10):1913-9. DOI: 10.1007/s00467-008-1108-3. View

12.

Byrne C, Ford D, Gilg J, Ansell D, Feehally J . UK Renal Registry 12th Annual Report (December 2009): chapter 3: UK ESRD incident rates in 2008: national and centre-specific analyses. Nephron Clin Pract. 2010; 115 Suppl 1:c9-39. DOI: 10.1159/000299800. View

13.

Deltas C, Mean R, Rossou E, Costi C, Koupepidou P, Hadjiyanni I . Familial Mediterranean fever (FMF) mutations occur frequently in the Greek-Cypriot population of Cyprus. Genet Test. 2002; 6(1):15-21. DOI: 10.1089/109065702760093861. View

14.

Perneger T, Whelton P, Klag M, Rossiter K . Diagnosis of hypertensive end-stage renal disease: effect of patient's race. Am J Epidemiol. 1995; 141(1):10-5. DOI: 10.1093/oxfordjournals.aje.a117338. View

15.

Irwin J, Saunier J, Strouss K, Paintner C, Diegoli T, Sturk K . Mitochondrial control region sequences from northern Greece and Greek Cypriots. Int J Legal Med. 2007; 122(1):87-9. DOI: 10.1007/s00414-007-0173-7. View

16.

Baysal E, Kleanthous M, Bozkurt G, Kyrri A, Kalogirou E, Angastiniotis M . alpha-Thalassaemia in the population of Cyprus. Br J Haematol. 1995; 89(3):496-9. DOI: 10.1111/j.1365-2141.1995.tb08354.x. View

17.

Suleymanlar G, Serdengecti K, Altiparmak M, Jager K, Seyahi N, Erek E . Trends in renal replacement therapy in Turkey, 1996-2008. Am J Kidney Dis. 2011; 57(3):456-65. DOI: 10.1053/j.ajkd.2010.12.007. View

18.

Suleymanlar G, Utas C, Arinsoy T, Ates K, Altun B, Altiparmak M . A population-based survey of Chronic REnal Disease In Turkey--the CREDIT study. Nephrol Dial Transplant. 2010; 26(6):1862-71. PMC: 3107767. DOI: 10.1093/ndt/gfq656. View

19.

Lubensky I, Schmidt L, Zhuang Z, Weirich G, Pack S, Zambrano N . Hereditary and sporadic papillary renal carcinomas with c-met mutations share a distinct morphological phenotype. Am J Pathol. 1999; 155(2):517-26. PMC: 1866853. DOI: 10.1016/S0002-9440(10)65147-4. View

20.

Olds T, Maher C, Zumin S, Peneau S, Lioret S, Castetbon K . Evidence that the prevalence of childhood overweight is plateauing: data from nine countries. Int J Pediatr Obes. 2011; 6(5-6):342-60. DOI: 10.3109/17477166.2011.605895. View