Minireview: Endoplasmic Reticulum Stress: Control in Protein, Lipid, and Signal Homeostasis

Overview

Journal Mol Endocrinol

Specialties Endocrinology
Molecular Biology

Date 2013 Jan 26

PMID 23349523

Citations 29

Authors

Jozsef Mandl

Tamas Meszaros

Gabor Banhegyi

Miklos Csala

Affiliations

Soon will be listed here.

Abstract

Endoplasmic reticulum (ER) stress is a regulatory mechanism that allows cells to adapt to a series of metabolic, redox, and other environmental changes. The role of ER stress was first identified in the maintenance of proteostasis. It has since been shown that ER stress is also critical to the regulation of lipid homeostasis, membrane turnover, and autophagy. ER stress initiates an intrinsic signaling network, the unfolded protein response, one component of the multifold and complex cellular signaling process system, which leads to major changes in the profiles of transcription factors. The unfolded protein response affects several other signaling routes through direct connections and also by indirect means. It directly influences hormone formation and life/death decisions at a cellular level; this relationship also involves connections to nutrient and environmental sensing-biotransformation processes. In conclusion, ER stress represents an integrated complex organelle response that makes an essential contribution to the maintenance of intracellular homeostasis.

Citing Articles

The Involvement of Calcium Channels in the Endoplasmic Reticulum Membrane in Nonalcoholic Fatty Liver Disease Pathogenesis.

Albalawi S, Aljabri A, Alshibani M, Al-Gayyar M Cureus. 2023; 15(11):e49150.

PMID: 38024063 PMC: 10663096. DOI: 10.7759/cureus.49150.

Endoplasmic Reticulum Stress Mediated NLRP3 Inflammasome Activation and Pyroptosis in THP-1 Macrophages Infected with .

Nie X, Ma B, Liu L, Yuan X, Li M, Liu Y Int J Mol Sci. 2023; 24(14).

PMID: 37511451 PMC: 10380357. DOI: 10.3390/ijms241411692.

Near-infrared-activated anticancer platinum(IV) complexes directly photooxidize biomolecules in an oxygen-independent manner.

Deng Z, Li H, Chen S, Wang N, Liu G, Liu D Nat Chem. 2023; 15(7):930-939.

PMID: 37353602 DOI: 10.1038/s41557-023-01242-w.

Glycogen-Endoplasmic Reticulum Connection in the Liver.

Mandl J Int J Mol Sci. 2023; 24(2).

PMID: 36674588 PMC: 9862463. DOI: 10.3390/ijms24021074.

PIDDosome-SCAP crosstalk controls high-fructose-diet-dependent transition from simple steatosis to steatohepatitis.

Kim J, Wang L, Sladky V, Oh T, Liu J, Trinh K Cell Metab. 2022; 34(10):1548-1560.e6.

PMID: 36041455 PMC: 9547947. DOI: 10.1016/j.cmet.2022.08.005.

References

Ding W, Ni H, Gao W, Hou Y, Melan M, Chen X . Differential effects of endoplasmic reticulum stress-induced autophagy on cell survival. J Biol Chem. 2006; 282(7):4702-4710. DOI: 10.1074/jbc.M609267200. View

Yellaturu C, Deng X, Park E, Raghow R, Elam M . Insulin enhances the biogenesis of nuclear sterol regulatory element-binding protein (SREBP)-1c by posttranscriptional down-regulation of Insig-2A and its dissociation from SREBP cleavage-activating protein (SCAP).SREBP-1c complex. J Biol Chem. 2009; 284(46):31726-34. PMC: 2797243. DOI: 10.1074/jbc.M109.050914. View

Ye J, Rawson R, Komuro R, Chen X, Dave U, Prywes R . ER stress induces cleavage of membrane-bound ATF6 by the same proteases that process SREBPs. Mol Cell. 2001; 6(6):1355-64. DOI: 10.1016/s1097-2765(00)00133-7. View

Piccirella S, Czegle I, Lizak B, Margittai E, Senesi S, Papp E . Uncoupled redox systems in the lumen of the endoplasmic reticulum. Pyridine nucleotides stay reduced in an oxidative environment. J Biol Chem. 2005; 281(8):4671-7. DOI: 10.1074/jbc.M509406200. View

Malhi H, Kaufman R . Endoplasmic reticulum stress in liver disease. J Hepatol. 2010; 54(4):795-809. PMC: 3375108. DOI: 10.1016/j.jhep.2010.11.005. View

Wang D, Wei Y, Pagliassotti M . Saturated fatty acids promote endoplasmic reticulum stress and liver injury in rats with hepatic steatosis. Endocrinology. 2005; 147(2):943-51. DOI: 10.1210/en.2005-0570. View

Radhakrishnan A, Ikeda Y, Kwon H, Brown M, Goldstein J . Sterol-regulated transport of SREBPs from endoplasmic reticulum to Golgi: oxysterols block transport by binding to Insig. Proc Natl Acad Sci U S A. 2007; 104(16):6511-8. PMC: 1851665. DOI: 10.1073/pnas.0700899104. View

Ozcan U, Ozcan L, Yilmaz E, Duvel K, Sahin M, Manning B . Loss of the tuberous sclerosis complex tumor suppressors triggers the unfolded protein response to regulate insulin signaling and apoptosis. Mol Cell. 2008; 29(5):541-51. PMC: 2361721. DOI: 10.1016/j.molcel.2007.12.023. View

Weber S, Chambers K, Bensch K, Scarim A, Corbett J . PPARgamma ligands induce ER stress in pancreatic beta-cells: ER stress activation results in attenuation of cytokine signaling. Am J Physiol Endocrinol Metab. 2004; 287(6):E1171-7. DOI: 10.1152/ajpendo.00331.2004. View

10.

Shimano H . SREBPs: physiology and pathophysiology of the SREBP family. FEBS J. 2009; 276(3):616-21. DOI: 10.1111/j.1742-4658.2008.06806.x. View

11.

Wang Y, Ong S, Chai S, Chen T . Role of CAR and PXR in xenobiotic sensing and metabolism. Expert Opin Drug Metab Toxicol. 2012; 8(7):803-17. PMC: 3593589. DOI: 10.1517/17425255.2012.685237. View

12.

Zhang K, Kaufman R . From endoplasmic-reticulum stress to the inflammatory response. Nature. 2008; 454(7203):455-62. PMC: 2727659. DOI: 10.1038/nature07203. View

13.

Lee A, Scapa E, Cohen D, Glimcher L . Regulation of hepatic lipogenesis by the transcription factor XBP1. Science. 2008; 320(5882):1492-6. PMC: 3620093. DOI: 10.1126/science.1158042. View

14.

Csala M, Kereszturi E, Mandl J, Banhegyi G . The endoplasmic reticulum as the extracellular space inside the cell: role in protein folding and glycosylation. Antioxid Redox Signal. 2011; 16(10):1100-8. DOI: 10.1089/ars.2011.4227. View

15.

Quan W, Hur K, Lim Y, Oh S, Lee J, Kim K . Autophagy deficiency in beta cells leads to compromised unfolded protein response and progression from obesity to diabetes in mice. Diabetologia. 2011; 55(2):392-403. DOI: 10.1007/s00125-011-2350-y. View

16.

Banhegyi G, Benedetti A, Fulceri R, Senesi S . Cooperativity between 11beta-hydroxysteroid dehydrogenase type 1 and hexose-6-phosphate dehydrogenase in the lumen of the endoplasmic reticulum. J Biol Chem. 2004; 279(26):27017-21. DOI: 10.1074/jbc.M404159200. View

17.

Hotamisligil G . Endoplasmic reticulum stress and the inflammatory basis of metabolic disease. Cell. 2010; 140(6):900-17. PMC: 2887297. DOI: 10.1016/j.cell.2010.02.034. View

18.

Honkakoski P, Negishi M . Regulation of cytochrome P450 (CYP) genes by nuclear receptors. Biochem J. 2000; 347(Pt 2):321-37. PMC: 1220963. DOI: 10.1042/0264-6021:3470321. View

19.

Yorimitsu T, Nair U, Yang Z, Klionsky D . Endoplasmic reticulum stress triggers autophagy. J Biol Chem. 2006; 281(40):30299-304. PMC: 1828866. DOI: 10.1074/jbc.M607007200. View

20.

Banhegyi G, Benedetti A, Csala M, Mandl J . Stress on redox. FEBS Lett. 2007; 581(19):3634-40. DOI: 10.1016/j.febslet.2007.04.028. View