Acute Toxicity and Early Cosmetic Outcome in Patients Treated with Multilumen Balloon Brachytherapy with Skin Spacing ≤ 7.0 Millimeters

Overview

Journal J Contemp Brachytherapy

Date 2013 Jan 25

PMID 23346134

Citations 5

Authors

Kiwhoon Lee

Amy Quillo

Dustin Dillon

Keith Sowards

Allison Hatmaker

Anthony Dragun

Affiliations

Soon will be listed here.

Abstract

Purpose: To review institutional experience treating patients who underwent breast conserving surgery and adjuvant accelerated partial breast irradiation with multilumen balloon brachytherapy (MLB) with close skin spacing (≤7 mm).

Material And Methods: Since July 2009, 26 patients with skin spacing ≤ 7.0 mm were treated with breast-conserving therapy and adjuvant MLB brachytherapy. Patients were treated with either the Contura or MammoSite ML catheter to a total dose of 34 Gy in 10 fractions. Patients were assessed for acute toxicity at the completion of treatment and 1-month post treatment. Cosmesis and late toxicity were assessed at three-month intervals thereafter.

Results: The median age of the patients was 56 years and median follow-up was 9 months. Sixteen patients had skin spacing of 5.0-7.0 mm, 10 with < 5.0 mm (median 5.8). The median percentage of the target (PTV_EVAL) receiving ≥ 95% of the prescription dose was 95.6%. The median volume of PTV_EVAL receiving ≥ 200% of the prescription dose was 6.1 cc. The maximum skin dose was 118.2% (median). The most commonly observed acute toxicity was grade 1-2 dermatitis (65.4%). The rate of post-treatment seroma and infection was 38.5% and 3.8%, respectively. Excellent/good cosmetic outcomes seen at the time of last follow-up was 92.3%.

Conclusions: MLB brachytherapy is safe and feasible in patients with close skin spacing, with acute toxicity and early cosmesis similar to other published series. These devices may broaden the application of balloon brachytherapy in patients previously excluded from this treatment based on anatomy.

Citing Articles

Clinical outcomes, toxicity, and cosmesis in breast cancer patients with close skin spacing treated with accelerated partial breast irradiation (APBI) using multi-lumen/catheter applicators.

Akhtari M, Abboud M, Szeja S, Pino R, Lewis G, Bass B J Contemp Brachytherapy. 2017; 8(6):497-504.

PMID: 28115955 PMC: 5241383. DOI: 10.5114/jcb.2016.64830.

WBRT vs. APBI: an interim report of patient satisfaction and outcomes.

Bitter S, Heffron-Cartwright P, Wennerstrom C, Weatherford J, Einstein D, Keiler L J Contemp Brachytherapy. 2016; 8(1):17-22.

PMID: 26985193 PMC: 4793068. DOI: 10.5114/jcb.2016.57816.

Brachytherapy in breast cancer: an effective alternative.

Skowronek J, Chichel A Prz Menopauzalny. 2015; 13(1):48-55.

PMID: 26327829 PMC: 4520341. DOI: 10.5114/pm.2014.41090.

[Calculation of the equivalent uniform dose for accelerated partial breast irradiation using the MammoSite applicator].

Haverkamp U, Moustakis C Strahlenther Onkol. 2014; 190(2):235-6.

PMID: 24408056 DOI: 10.1007/s00066-013-0524-x.

Current modalities of accelerated partial breast irradiation.

Cox J, Swanson T Nat Rev Clin Oncol. 2013; 10(6):344-56.

PMID: 23629470 DOI: 10.1038/nrclinonc.2013.65.

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