Susceptibility of Human Iris Stromal Cells to Herpes Simplex Virus 1 Entry

Overview

Journal J Virol

Publisher American Society for Microbiology

Date 2013 Jan 25

PMID 23345512

Citations 5

Authors

John Baldwin

Paul J Park

Brian Zanotti

Erika Maus

Michael V Volin

Deepak Shukla

Vaibhav Tiwari

Affiliations

Soon will be listed here.

Abstract

Ocular herpes simplex virus 1 (HSV-1) infection can lead to multiple complications, including iritis, an inflammation of the iris. Here, we use human iris stroma cells as a novel in vitro model to demonstrate HSV-1 entry and the inflammatory mediators that can damage the iris. The upregulated cytokines observed in this study provide a new understanding of the intrinsic immune mechanisms that can contribute to the onset of iritis.

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