Regulatory Networks Defining EMT During Cancer Initiation and Progression

Overview

Journal Nat Rev Cancer

Specialty Oncology

Date 2013 Jan 25

PMID 23344542

Citations 1366

Authors

Bram De Craene

Geert Berx

Affiliations

Soon will be listed here.

Abstract

Epithelial to mesenchymal transition (EMT) is essential for driving plasticity during development, but is an unintentional behaviour of cells during cancer progression. The EMT-associated reprogramming of cells not only suggests that fundamental changes may occur to several regulatory networks but also that an intimate interplay exists between them. Disturbance of a controlled epithelial balance is triggered by altering several layers of regulation, including the transcriptional and translational machinery, expression of non-coding RNAs, alternative splicing and protein stability.

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