Verification of Skin Autofluorescence Values by Mass Spectrometry in Adolescents with Type 1 Diabetes: Brief Report

Overview

Journal Diabetes Technol Ther

Specialties Endocrinology
Pharmacology

Date 2013 Jan 25

PMID 23343332

Citations 4

Authors

Emilia Macsai

Zoltan Takats

Laszlo Derzbach

Anna Korner

Barna Vasarhelyi

Affiliations

Soon will be listed here.

Abstract

Background: Accumulation of advanced glycation end products (AGEs) in tissues is a major risk factor for diabetes-associated complications. Skin autofluorescence (SAF) values measured by a specific noninvasive approach (AGE Reader; DiagnOptics Technologies B.V., Gröningen, The Netherlands) reflect the overall AGE exposure in skin.

Subjects And Methods: In 16 adolescents with type 1 diabetes (age range, 11-18 years) we tested the association between SAF measured with an AGE Reader and the presence of glucuronic acid, 3-indoxyl sulfate, 3-hydroxybutyrate, phenol sulfate, and pentosidine in skin tissue determined with desorption electrospray ionization mass spectrometry (DESI-MS). These compounds are implicated in long-term diabetes complications.

Results: SAF values significantly correlated with levels of compounds measured by DESI-MS (r>0.9 and P<0.001 for each).

Conclusions: The strong correlation between adolescents' SAF values measured with the AGE Reader and some glycation products measured with DESI-MS indicates that SAF values may be used as surrogate markers of skin exposure to glycemic end products in type 1 diabetes.

Citing Articles

Genome-wide association study identifies novel loci associated with skin autofluorescence in individuals without diabetes.

Vollenbrock C, Roshandel D, van der Klauw M, Wolffenbuttel B, Paterson A BMC Genomics. 2022; 23(1):840.

PMID: 36536295 PMC: 9764523. DOI: 10.1186/s12864-022-09062-x.

Advanced glycation end products as predictors of renal function in youth with type 1 diabetes.

Forbes J, Le Bagge S, Righi S, Fotheringham A, Gallo L, McCarthy D Sci Rep. 2021; 11(1):9422.

PMID: 33941808 PMC: 8093271. DOI: 10.1038/s41598-021-88786-4.

Skin advanced glycation end products as biomarkers of photosensitivity in schizophrenia.

Tani E, Ohnuma T, Hirose H, Nakayama K, Mao W, Nakadaira M Int J Methods Psychiatr Res. 2019; 28(1):e1769.

PMID: 30701623 PMC: 6877242. DOI: 10.1002/mpr.1769.

Evidence of glucuronidation of the glycation product LW-1: tentative structure and implications for the long-term complications of diabetes.

Sell D, Nemet I, Liang Z, Monnier V Glycoconj J. 2018; 35(2):177-190.

PMID: 29305779 PMC: 5920740. DOI: 10.1007/s10719-017-9810-7.