DNA Analysis of an Early Modern Human from Tianyuan Cave, China

Overview

Journal Proc Natl Acad Sci U S A

Specialty Science

Date 2013 Jan 24

PMID 23341637

Citations 217

Authors

Qiaomei Fu

Matthias Meyer

Xing Gao

Udo Stenzel

Hernan A Burbano

Janet Kelso

Svante Paabo

Affiliations

Soon will be listed here.

Abstract

Hominins with morphology similar to present-day humans appear in the fossil record across Eurasia between 40,000 and 50,000 y ago. The genetic relationships between these early modern humans and present-day human populations have not been established. We have extracted DNA from a 40,000-y-old anatomically modern human from Tianyuan Cave outside Beijing, China. Using a highly scalable hybridization enrichment strategy, we determined the DNA sequences of the mitochondrial genome, the entire nonrepetitive portion of chromosome 21 (∼30 Mbp), and over 3,000 polymorphic sites across the nuclear genome of this individual. The nuclear DNA sequences determined from this early modern human reveal that the Tianyuan individual derived from a population that was ancestral to many present-day Asians and Native Americans but postdated the divergence of Asians from Europeans. They also show that this individual carried proportions of DNA variants derived from archaic humans similar to present-day people in mainland Asia.

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