Alpha 2.0
Login Register
» Articles » PMID: 2334162

Ciprofloxacin Concentrations and Impact of the Colon Microflora in Patients Undergoing Colorectal Surgery

Overview
Journal Antimicrob Agents Chemother
Publisher American Society for Microbiology
Specialty Pharmacology
Date 1990 Mar 1
PMID 2334162
Citations 24
Authors
B BRISMAR
C Edlund
A S MALMBORG
C E Nord
Affiliations
Soon will be listed here.
Abstract

Ciprofloxacin was given perorally in two doses of 750 mg each with a 12-h interval starting 24 h prior to surgery, 400 mg of ciprofloxacin was given intravenously at the induction of anesthesia, and 400 mg of ciprofloxacin was given 12 h later to 21 patients undergoing elective colorectal surgery. The maximum concentrations in serum (mean value +/- standard deviation, 11.1 +/- 7.8 mg/liter) during surgery were reached 30 min after ciprofloxacin was administered. The ciprofloxacin concentrations in the intestinal mucosa samples were 2.7 to 37.8 mg/kg of tissue weight, and the concentrations in the fecal samples were less than 0.1 to 858 mg/kg. The aerobic and anaerobic bacteria in the fecal flora were suppressed markedly during the prophylaxis period. No postoperative infections occurred.

Citing Articles

Antibiotics promote intestinal growth of carbapenem-resistant Enterobacteriaceae by enriching nutrients and depleting microbial metabolites.

Yip A, King O, Omelchenko O, Kurkimat S, Horrocks V, Mostyn P Nat Commun. 2023; 14(1):5094.

PMID: 37607936 PMC: 10444851. DOI: 10.1038/s41467-023-40872-z.

Non-Toxigenic Strain E4 (NTCD-E4) Prevents Establishment of Primary Infection by Epidemic PCR Ribotype 027 in an In Vitro Human Gut Model.

Etifa P, Rodriguez C, Harmanus C, Sanders I, Sidorov I, Mohammed O Antibiotics (Basel). 2023; 12(3).

PMID: 36978302 PMC: 10044524. DOI: 10.3390/antibiotics12030435.

Ciprofloxacin Pharmacokinetics After Oral and Intravenous Administration in (Morbidly) Obese and Non-obese Individuals: A Prospective Clinical Study.

van Rhee K, Smit C, Wasmann R, van der Linden P, Wiezer R, van Dongen E Clin Pharmacokinet. 2022; 61(8):1167-1175.

PMID: 35641862 PMC: 9349153. DOI: 10.1007/s40262-022-01130-5.

Impact of Levofloxacin for the Prophylaxis of Bloodstream Infection on the Gut Microbiome in Patients With Hematologic Malignancy.

Ziegler M, Han J, Landsburg D, Pegues D, Reesey E, Gilmar C Open Forum Infect Dis. 2019; 6(7):ofz252.

PMID: 31281857 PMC: 6602896. DOI: 10.1093/ofid/ofz252.

Antibiotic treatment for Tuberculosis induces a profound dysbiosis of the microbiome that persists long after therapy is completed.

Wipperman M, Fitzgerald D, Juste M, Taur Y, Namasivayam S, Sher A Sci Rep. 2017; 7(1):10767.

PMID: 28883399 PMC: 5589918. DOI: 10.1038/s41598-017-10346-6.

References
1.
Kager L, Ljungdahl I, MALMBORG A, Nord C, Pieper R, Dahlgren P . Antibiotic prophylaxis with cefoxitin in colorectal surgery: effect on the colon microflora and septic complications--a clinical model for prediction of the benefit and risks in using a new antibiotic in prophylaxis. Ann Surg. 1981; 193(3):277-82. PMC: 1345062. DOI: 10.1097/00000658-198103000-00005. View
2.
Chin N, Neu H . Ciprofloxacin, a quinolone carboxylic acid compound active against aerobic and anaerobic bacteria. Antimicrob Agents Chemother. 1984; 25(3):319-26. PMC: 185508. DOI: 10.1128/AAC.25.3.319. View
3.
Wingender W, Graefe K, Gau W, Forster D, Beermann D, Schacht P . Pharmacokinetics of ciprofloxacin after oral and intravenous administration in healthy volunteers. Eur J Clin Microbiol. 1984; 3(4):355-9. DOI: 10.1007/BF01977494. View
4.
MALMBORG A . Antibiotic concentrations in intestinal mucosa. Scand J Infect Dis Suppl. 1985; 44:59-62. View
5.
LJUNGQVIST U . WOUND SEPSIS AFTER CLEAN OPERATIONS. Lancet. 1964; 1(7342):1095-7. DOI: 10.1016/s0140-6736(64)91291-7. View