MicroRNA-135b Acts As a Tumor Promoter by Targeting the Hypoxia-inducible Factor Pathway in Genetically Defined Mouse Model of Head and Neck Squamous Cell Carcinoma

Overview

Journal Cancer Lett

Specialty Oncology

Date 2013 Jan 24

PMID 23340180

Citations 48

Authors

Lu Zhang

Zhi-Jun Sun

Yansong Bian

Ashok B Kulkarni

Affiliations

Soon will be listed here.

Abstract

Here in, we investigated the mechanism underlying overexpression of miR-135b in the human head and neck squamous cell carcinoma (HNSCC) cell lines and in the HNSCC mouse model. Exogenous expression of miR-135b in these cell lines increased cell proliferation, migration, and colony formation. Gene silencing analysis revealed that miR-135b affects a regulator that inhibits hypoxia-inducible factor (HIF). Increased miR-135b expression was positively correlated with HIF-1α expression and microvessel density in the HNSCC model. Thus, our data demonstrate that miR-135b acts as a tumor promoter by promoting cancer cell proliferation, colony formation, survival, and angiogenesis through activation of HIF-1α in HNSCC.

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