Present and Future Cell Therapies for Pancreatic Beta Cell Replenishment

Overview

Journal World J Gastroenterol

Publisher Baishideng Publishing Group

Specialty Gastroenterology

Date 2013 Jan 17

PMID 23322984

Citations 10

Authors

Juan Dominguez-Bendala

Camillo Ricordi

Affiliations

Soon will be listed here.

Abstract

If only at a small scale, islet transplantation has successfully addressed what ought to be the primary endpoint of any cell therapy: the functional replenishment of damaged tissue in patients. After years of less-than-optimal approaches to immunosuppression, recent advances consistently yield long-term graft survival rates comparable to those of whole pancreas transplantation. Limited organ availability is the main hurdle that stands in the way of the widespread clinical utilization of this pioneering intervention. Progress in stem cell research over the past decade, coupled with our decades-long experience with islet transplantation, is shaping the future of cell therapies for the treatment of diabetes. Here we review the most promising avenues of research aimed at generating an inexhaustible supply of insulin-producing cells for islet regeneration, including the differentiation of pluripotent and multipotent stem cells of embryonic and adult origin along the beta cell lineage and the direct reprogramming of non-endocrine tissues into insulin-producing cells.

Citing Articles

Expression of Pfkfb isoenzymes during in vitro differentiation of mouse embryonic stem cells into insulin-producing cells.

Guzel S, Yalcin A, Gurpinar Y, Guler S Turk J Med Sci. 2024; 53(6):1565-1573.

PMID: 38813509 PMC: 10760535. DOI: 10.55730/1300-0144.5725.

FasL microgels induce immune acceptance of islet allografts in nonhuman primates.

Lei J, Coronel M, Yolcu E, Deng H, Grimany-Nuno O, Hunckler M Sci Adv. 2022; 8(19):eabm9881.

PMID: 35559682 PMC: 9106299. DOI: 10.1126/sciadv.abm9881.

Delivery of therapeutic agents and cells to pancreatic islets: Towards a new era in the treatment of diabetes.

Zeynaloo E, Stone L, Dikici E, Ricordi C, Deo S, Bachas L Mol Aspects Med. 2021; 83:101063.

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Enhancing islet transplantation using a biocompatible collagen-PDMS bioscaffold enriched with dexamethasone-microplates.

Primavera R, Razavi M, Kevadiya B, Wang J, Vykunta A, Di Mascolo D Biofabrication. 2021; 13(3).

PMID: 33455953 PMC: 8530023. DOI: 10.1088/1758-5090/abdcac.

Improving the Function and Engraftment of Transplanted Pancreatic Islets Using Pulsed Focused Ultrasound Therapy.

Razavi M, Zheng F, Telichko A, Wang J, Ren G, Dahl J Sci Rep. 2019; 9(1):13416.

PMID: 31527773 PMC: 6746980. DOI: 10.1038/s41598-019-49933-0.

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