A Pri-miR-218 Variant and Risk of Cervical Carcinoma in Chinese Women

Overview

Journal BMC Cancer

Publisher Biomed Central

Specialty Oncology

Date 2013 Jan 17

PMID 23320911

Citations 26

Authors

Ting-Yan Shi

Xiao-Jun Chen

Mei-Ling Zhu

Meng-Yun Wang

Jing He

Ke-Da Yu

Zhi-Ming Shao

Meng-Hong Sun

Xiao-yan Zhou

Xi Cheng

Xiaohua Wu

Qingyi Wei

Affiliations

Soon will be listed here.

Abstract

Background: MicroRNA (miRNA)-related single nucleotide polymorphisms (SNPs) may compromise miRNA binding affinity and modify mRNA expression levels of the target genes, thus leading to cancer susceptibility. However, few studies have investigated roles of miRNA-related SNPs in the etiology of cervical carcinoma.

Methods: In this case-control study of 1,584 cervical cancer cases and 1,394 cancer-free female controls, we investigated associations between two miR-218-related SNPs involved in the LAMB3-miR-218 pathway and the risk of cervical carcinoma in Eastern Chinese women.

Results: We found that the pri-miR-218 rs11134527 variant GG genotype was significantly associated with a decreased risk of cervical carcinoma compared with AA/AG genotypes (adjusted OR=0.77, 95% CI=0.63-0.95, P=0.015). However, this association was not observed for the miR-218 binding site SNP (rs2566) on LAMB3. Using the multifactor dimensionality reduction analysis, we observed some evidence of interactions of these two SNPs with other risk factors, especially age at primiparity and menopausal status, in the risk of cervical carcinoma.

Conclusions: The pri-miR-218 rs11134527 SNP was significantly associated with the risk of cervical carcinoma in Eastern Chinese women. Larger, independent studies are warranted to validate our findings.

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References

Chen A, Yu K, Fan L, Li J, Yang C, Huang A . Germline genetic variants disturbing the Let-7/LIN28 double-negative feedback loop alter breast cancer susceptibility. PLoS Genet. 2011; 7(9):e1002259. PMC: 3164678. DOI: 10.1371/journal.pgen.1002259. View

Wacholder S, Chanock S, Garcia-Closas M, El Ghormli L, Rothman N . Assessing the probability that a positive report is false: an approach for molecular epidemiology studies. J Natl Cancer Inst. 2004; 96(6):434-42. PMC: 7713993. DOI: 10.1093/jnci/djh075. View

Zhang L, Huang J, Yang N, Greshock J, Megraw M, Giannakakis A . microRNAs exhibit high frequency genomic alterations in human cancer. Proc Natl Acad Sci U S A. 2006; 103(24):9136-41. PMC: 1474008. DOI: 10.1073/pnas.0508889103. View

Yanaihara N, Caplen N, Bowman E, Seike M, Kumamoto K, Yi M . Unique microRNA molecular profiles in lung cancer diagnosis and prognosis. Cancer Cell. 2006; 9(3):189-98. DOI: 10.1016/j.ccr.2006.01.025. View

Galvan A, Ioannidis J, Dragani T . Beyond genome-wide association studies: genetic heterogeneity and individual predisposition to cancer. Trends Genet. 2010; 26(3):132-41. PMC: 2826571. DOI: 10.1016/j.tig.2009.12.008. View

Tie J, Pan Y, Zhao L, Wu K, Liu J, Sun S . MiR-218 inhibits invasion and metastasis of gastric cancer by targeting the Robo1 receptor. PLoS Genet. 2010; 6(3):e1000879. PMC: 2837402. DOI: 10.1371/journal.pgen.1000879. View

Jemal A, Bray F, Center M, Ferlay J, Ward E, Forman D . Global cancer statistics. CA Cancer J Clin. 2011; 61(2):69-90. DOI: 10.3322/caac.20107. View

Calin G, Croce C . MicroRNA-cancer connection: the beginning of a new tale. Cancer Res. 2006; 66(15):7390-4. DOI: 10.1158/0008-5472.CAN-06-0800. View

Davidson M, Larsen J, Yang I, Hayward N, Clarke B, Duhig E . MicroRNA-218 is deleted and downregulated in lung squamous cell carcinoma. PLoS One. 2010; 5(9):e12560. PMC: 2933228. DOI: 10.1371/journal.pone.0012560. View

10.

Skyldberg B, Salo S, Eriksson E, Aspenblad U, Moberger B, Tryggvason K . Laminin-5 as a marker of invasiveness in cervical lesions. J Natl Cancer Inst. 1999; 91(21):1882-7. DOI: 10.1093/jnci/91.21.1882. View

11.

Marinkovich M . Tumour microenvironment: laminin 332 in squamous-cell carcinoma. Nat Rev Cancer. 2007; 7(5):370-80. DOI: 10.1038/nrc2089. View

12.

Reshmi G, Surya R, Jissa V, Babu P, Preethi N, Santhi W . C-T variant in a miRNA target site of BCL2 is associated with increased risk of human papilloma virus related cervical cancer--an in silico approach. Genomics. 2011; 98(3):189-93. DOI: 10.1016/j.ygeno.2011.06.005. View

13.

Li Y, Liu J, Yuan C, Cui B, Zou X, Qiao Y . High-risk human papillomavirus reduces the expression of microRNA-218 in women with cervical intraepithelial neoplasia. J Int Med Res. 2011; 38(5):1730-6. DOI: 10.1177/147323001003800518. View

14.

Saunders M, Liang H, Li W . Human polymorphism at microRNAs and microRNA target sites. Proc Natl Acad Sci U S A. 2007; 104(9):3300-5. PMC: 1805605. DOI: 10.1073/pnas.0611347104. View

15.

Ritchie M, Hahn L, Roodi N, BAILEY L, Dupont W, Parl F . Multifactor-dimensionality reduction reveals high-order interactions among estrogen-metabolism genes in sporadic breast cancer. Am J Hum Genet. 2001; 69(1):138-47. PMC: 1226028. DOI: 10.1086/321276. View

16.

Kertesz M, Iovino N, Unnerstall U, Gaul U, Segal E . The role of site accessibility in microRNA target recognition. Nat Genet. 2007; 39(10):1278-84. DOI: 10.1038/ng2135. View

17.

Liu Z, Wei S, Ma H, Zhao M, Myers J, Weber R . A functional variant at the miR-184 binding site in TNFAIP2 and risk of squamous cell carcinoma of the head and neck. Carcinogenesis. 2011; 32(11):1668-74. PMC: 3204352. DOI: 10.1093/carcin/bgr209. View

18.

Guan P, Howell-Jones R, Li N, Bruni L, de Sanjose S, Franceschi S . Human papillomavirus types in 115,789 HPV-positive women: a meta-analysis from cervical infection to cancer. Int J Cancer. 2012; 131(10):2349-59. DOI: 10.1002/ijc.27485. View

19.

Alajez N, Lenarduzzi M, Ito E, Hui A, Shi W, Bruce J . MiR-218 suppresses nasopharyngeal cancer progression through downregulation of survivin and the SLIT2-ROBO1 pathway. Cancer Res. 2011; 71(6):2381-91. DOI: 10.1158/0008-5472.CAN-10-2754. View

20.

He J, Qiu L, Wang M, Hua R, Zhang R, Yu H . Polymorphisms in the XPG gene and risk of gastric cancer in Chinese populations. Hum Genet. 2012; 131(7):1235-44. DOI: 10.1007/s00439-012-1152-8. View