Straightforward Synthesis of Thiazoline-incorporated Chalconoids from Phenacyl Halides

Overview

Journal Mol Divers

Date 2013 Jan 15

PMID 23314739

Citations 1

Authors

Adile Ayati

Saeed Emami

Affiliations

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Abstract

A series of thiazoline-incorporated chalconoids, designed based on natural product scaffold, were efficiently synthesized via the reaction of 3-methyl-4-arylthiazole-2(3H)-thiones and appropriate phenacyl halides, and subsequent desulfurization. The starting 3-methyl-4- arylthiazole-2(3H)-thiones were also prepared from phenacyl halides. The structural aspects and (Z)-geometry of compounds were confirmed by IR and (1)H NMR spectral data. This chemistry provides a new library of compounds basically originated from phenacyl halides as building blocks, with potential activity for biomedical screening.

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