Antifungal Activity of Chalcones: a Mechanistic Study Using Various Yeast Strains

Overview

Journal Eur J Med Chem

Specialty Chemistry

Date 2008 Feb 19

PMID 18280009

Citations 42

Authors

K L Lahtchev

D I Batovska

St P Parushev

V M Ubiyvovk

a a Sibirny

Affiliations

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Abstract

We reported the synthesis, antifungal evaluation and study on substituent effects of 21 chalcones. A lot of genetically defined strains belonging to different yeast genera and species, namely Saccharomyces cerevisiae, Hansenula polymorpha and Kluyveromyces lactis, were used as test organisms. Concerning the mode of the antifungal action of chalcones it was shown that DNA was probably not the main target for the chalcones. It was revealed that the yeast's intracellular glutathione and cysteine molecules play significant role as defence barrier against the chalcone action. It was also shown that chalcones may react with some proteins involved in cell separation.

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