Dual Core Processing: MRB1 is an Emerging Kinetoplast RNA Editing Complex

Overview

Journal Trends Parasitol

Specialty Parasitology

Date 2013 Jan 12

PMID 23305619

Citations 44

Authors

Hassan Hashimi

Sara L Zimmer

Michelle L Ammerman

Laurie K Read

Julius Lukes

Affiliations

Soon will be listed here.

Abstract

Our understanding of kinetoplastid RNA (kRNA) editing has centered on this paradigm: guide RNAs (gRNAs) provide a blueprint for uridine insertion/deletion into mitochondrial mRNAs by the RNA editing core complex (RECC). The characterization of constituent subunits of the mitochondrial RNA-binding complex 1 (MRB1) implies that it too is vital to the editing process. The recently elucidated MRB1 architecture will be instrumental in putting functional data from individual subunits into context. Our model depicts two functions for MRB1: mediating multi-round kRNA editing by coordinating the exchange of multiple gRNAs required by RECC to edit lengthy regions of mRNAs, and then linking kRNA editing with other RNA processing events.

Citing Articles

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