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Gastric Acid, Calcium Absorption, and Their Impact on Bone Health

Overview
Journal Physiol Rev
Specialty Physiology
Date 2013 Jan 11
PMID 23303909
Citations 69
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Abstract

Calcium balance is essential for a multitude of physiological processes, ranging from cell signaling to maintenance of bone health. Adequate intestinal absorption of calcium is a major factor for maintaining systemic calcium homeostasis. Recent observations indicate that a reduction of gastric acidity may impair effective calcium uptake through the intestine. This article reviews the physiology of gastric acid secretion, intestinal calcium absorption, and their respective neuroendocrine regulation and explores the physiological basis of a potential link between these individual systems.

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