Association Between Body Weight at Weaning and Remodeling in the Subcutaneous Adipose Tissue of Obese Adult Mice with Undernourishment in Utero

Overview

Journal Reprod Sci

Publisher Springer

Specialty Reproductive Medicine

Date 2013 Jan 9

PMID 23296035

Citations 8

Authors

Yukiko Kobayashi Kohmura

Naohiro Kanayama

Keiko Muramatsu

Naoaki Tamura

Chizuko Yaguchi

Toshiyuki Uchida

Kazunao Suzuki

Kazuhiro Sugihara

Seiichiro Aoe

Takeshi Sasaki

Takayoshi Suganami

Yoshihiro Ogawa

Hiroaki Itoh

Affiliations

Soon will be listed here.

Abstract

Rapid growth in infancy considerably increases the risk of obesity and metabolic disorders in adulthood especially among neonates born small. To investigate the mechanism involved, we developed an animal model of undernourishment in utero by maternal caloric restriction, in which the Z scores of body weight at weaning (19.5 days) positively correlated with parameters of obesity, metabolic disorders, and remodeling of subcutaneous adipose tissue, such as numbers of macrophages in adipose tissue, the ratio of inflammatory M1 to anti-inflammatory M2 macrophages, estimated by gene expression of specific antigens, and the relative ratio of small adipocytes less than 30 μm in diameter, on a high-fat diet at 17 weeks of age. To our knowledge, this is the first report of a possible connection between infantile body weight and adipose tissue remodeling in obesity after undernourishment in utero.

Citing Articles

Comparative Analysis of Gene Expression Profiles in the Adipose Tissue of Obese Adult Mice With Rapid Infantile Growth After Undernourishment .

Suzuki M, Kohmura-Kobayashi Y, Ueda M, Furuta-Isomura N, Matsumoto M, Oda T Front Endocrinol (Lausanne). 2022; 13:818064.

PMID: 35295992 PMC: 8920555. DOI: 10.3389/fendo.2022.818064.

Developmental Origins of Metaflammation; A Bridge to the Future Between the DOHaD Theory and Evolutionary Biology.

Itoh H, Ueda M, Suzuki M, Kohmura-Kobayashi Y Front Endocrinol (Lausanne). 2022; 13:839436.

PMID: 35185805 PMC: 8850935. DOI: 10.3389/fendo.2022.839436.

Feed Composition Differences Resulting from Organic and Conventional Farming Practices Affect Physiological Parameters in Wistar Rats-Results from a Factorial, Two-Generation Dietary Intervention Trial.

Baranski M, Srednicka-Tober D, Rempelos L, Hasanaliyeva G, Gromadzka-Ostrowska J, Skwarlo-Sonta K Nutrients. 2021; 13(2).

PMID: 33530419 PMC: 7911726. DOI: 10.3390/nu13020377.

Maternal tadalafil therapy for fetal growth restriction prevents non-alcoholic fatty liver disease and adipocyte hypertrophy in the offspring.

Kawamura T, Tanaka H, Tachibana R, Yoshikawa K, Maki S, Toriyabe K Sci Rep. 2021; 11(1):1186.

PMID: 33441894 PMC: 7806616. DOI: 10.1038/s41598-020-80643-0.

Plasticity of histone modifications around Cidea and Cidec genes with secondary bile in the amelioration of developmentally-programmed hepatic steatosis.

Urmi J, Itoh H, Muramatsu-Kato K, Kohmura-Kobayashi Y, Hariya N, Jain D Sci Rep. 2019; 9(1):17100.

PMID: 31745102 PMC: 6863835. DOI: 10.1038/s41598-019-52943-7.

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