Liver Fatty Acid-binding Protein is a Diagnostic Marker to Detect Liver Injury Due to Chronic Hepatitis C Infection

Overview

Journal Arch Med Res

Specialty General Medicine

Date 2013 Jan 8

PMID 23291381

Citations 18

Authors

Erdem Akbal

Seyfettin Koklu

Erdem Kocak

Basak Cakal

Fahri Gunes

Omer Basar

Yasar Tuna

Mehmet Senes

Affiliations

Soon will be listed here.

Abstract

Background And Aims: Liver fatty acid-binding protein (L-FABP) is a small molecule. The aim of this study was to examine L-FABP levels and to detect its diagnostic value in chronic hepatitis C (CHC).

Methods: We studied 22 patients with CHC and 20 healthy control subjects. Patients with persistently elevated serum aminotransferases and positive HCV RNA were included in the study. Patients with CHC underwent percutaneous liver biopsy. Serum level of L-FABP was determined by ELISA method.

Results: Patients with CHC had significantly increased levels of L-FABP compared to controls. A strong correlation between serum L-FABP concentrations and aspartate aminotransferases, alanine aminotransferases, HCV RNA levels and hepatic inflammation was found. When a cut-off value was 29,000 pg/mL for L-FABP, sensitivity and specificity were 75 and 100%, respectively. Positive and negative predictive values for L-FABP were 100 and 78%, respectively.

Conclusions: Serum L-FABP is used as a new diagnostic marker to detect liver injury.

Citing Articles

Limited Diagnostic Value of miRNAs in Early Trauma-Induced Liver Injury: Only miRNA-122 Emerges as a Late-Phase Marker.

Horauf J, Singh A, Voth M, Moheimani H, Schindler C, Relja B Diagnostics (Basel). 2025; 15(2).

PMID: 39857063 PMC: 11764008. DOI: 10.3390/diagnostics15020179.

The potential value of fatty acid binding protein 1 in Chronic HBV-related liver disease progression assessment.

Ma S, Li X, Wu C, Wulayin K, Li M, Zhou L BMC Infect Dis. 2024; 24(1):1214.

PMID: 39468469 PMC: 11520826. DOI: 10.1186/s12879-024-10114-8.

Fatty-Acid-Binding Proteins: From Lipid Transporters to Disease Biomarkers.

Gaffar S, Aathirah A Biomolecules. 2023; 13(12).

PMID: 38136624 PMC: 10741572. DOI: 10.3390/biom13121753.

Mechanism Analysis of Metabolic Fatty Liver on Largemouth Bass () Based on Integrated Lipidomics and Proteomics.

Xue M, Yao T, Xue M, Francis F, Qin Y, Jia M Metabolites. 2022; 12(8).

PMID: 36005631 PMC: 9415018. DOI: 10.3390/metabo12080759.

Maternal Fatty Acid Metabolism in Pregnancy and Its Consequences in the Feto-Placental Development.

Duttaroy A, Basak S Front Physiol. 2022; 12:787848.

PMID: 35126178 PMC: 8811195. DOI: 10.3389/fphys.2021.787848.