Human Cytomegalovirus UL34 Binds to Multiple Sites Within the Viral Genome

Overview

Journal J Virol

Publisher American Society for Microbiology

Date 2013 Jan 4

PMID 23283944

Citations 6

Authors

Ziqi Liu

Bonita J Biegalke

Affiliations

Soon will be listed here.

Abstract

The human cytomegalovirus UL34 gene encodes a sequence-specific DNA binding protein that downregulates expression of the viral immune evasion gene US3. Analysis of the viral genome identified 14 potential UL34 binding sites. Using mobility shift experiments, UL34 bound to all predicted sites that were assayed (7 of 14). Furthermore, the UL34 binding site present within the regulatory region of the US9 gene downregulates expression in a manner similar to that seen for the US3 gene.

Citing Articles

Insights into the Transcriptome of Human Cytomegalovirus: A Comprehensive Review.

Zeng J, Cao D, Yang S, Jaijyan D, Liu X, Wu S Viruses. 2023; 15(8).

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UL34 Deletion Restricts Human Cytomegalovirus Capsid Formation and Maturation.

Turner D, Templin R, Barugahare A, Russ B, Turner S, Ramm G Int J Mol Sci. 2022; 23(10).

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Mouse Cytomegalovirus Encodes a Non-essential, Nuclear, - Expressed Protein Required for Efficient Viral Replication.

Eilbrecht M, Le-Trilling V, Trilling M Front Cell Infect Microbiol. 2020; 10:171.

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pUL34 binding near the human cytomegalovirus origin of lytic replication enhances DNA replication and viral growth.

Slayton M, Hossain T, Biegalke B Virology. 2018; 518:414-422.

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Human cytomegalovirus UL34 early and late proteins are essential for viral replication.

Rana R, Biegalke B Viruses. 2014; 6(2):476-88.

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