Characterization of the Human Cytomegalovirus UL34 Gene

Overview

Journal J Virol

Publisher American Society for Microbiology

Date 2004 Aug 17

PMID 15308752

Citations 12

Authors

B J Biegalke

E Lester

A Branda

R Rana

Affiliations

Soon will be listed here.

Abstract

UL34 encodes the transcriptional repressor of the human cytomegalovirus immune evasion gene, US3, and is essential for viral replication in tissue culture. Two different monocistronic transcripts originate from UL34 at early and late times postinfection and encode two predominant proteins and a third, minor protein. The UL34 proteins are differentially expressed throughout the viral replication cycle, with both proteins localizing to the nucleus and repressing expression of the US3 gene.

Citing Articles

Insights into the Transcriptome of Human Cytomegalovirus: A Comprehensive Review.

Zeng J, Cao D, Yang S, Jaijyan D, Liu X, Wu S Viruses. 2023; 15(8).

PMID: 37632045 PMC: 10458407. DOI: 10.3390/v15081703.

UL34 Deletion Restricts Human Cytomegalovirus Capsid Formation and Maturation.

Turner D, Templin R, Barugahare A, Russ B, Turner S, Ramm G Int J Mol Sci. 2022; 23(10).

PMID: 35628580 PMC: 9143689. DOI: 10.3390/ijms23105773.

The m15 Locus of Murine Cytomegalovirus Modulates Natural Killer Cell Responses to Promote Dissemination to the Salivary Glands and Viral Shedding.

Chan B, Arapovic M, Masters L, Rwandamuiye F, Jonjic S, Smith L Pathogens. 2021; 10(7).

PMID: 34358016 PMC: 8308470. DOI: 10.3390/pathogens10070866.

Mouse Cytomegalovirus Encodes a Non-essential, Nuclear, - Expressed Protein Required for Efficient Viral Replication.

Eilbrecht M, Le-Trilling V, Trilling M Front Cell Infect Microbiol. 2020; 10:171.

PMID: 32432049 PMC: 7214618. DOI: 10.3389/fcimb.2020.00171.

pUL34 binding near the human cytomegalovirus origin of lytic replication enhances DNA replication and viral growth.

Slayton M, Hossain T, Biegalke B Virology. 2018; 518:414-422.

PMID: 29626748 PMC: 5937935. DOI: 10.1016/j.virol.2018.03.017.

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