In Vivo Selection for Transmissible Drug Resistance in Salmonella Typhi During Antimicrobial Therapy

Overview

Journal Antimicrob Agents Chemother

Publisher American Society for Microbiology

Specialty Pharmacology

Date 1990 Jan 1

PMID 2327754

Citations 8

Authors

R S Schwalbe

C W Hoge

J G Morris Jr

P N OHanlon

R A Crawford

P H Gilligan

Affiliations

Soon will be listed here.

Abstract

We report the recovery of Salmonella typhi that acquired resistance to ampicillin, chloramphenicol, trimethoprim-sulfamethoxazole, and gentamicin subsequent to multiple antibiotic therapy. Escherichia coli and Klebsiella pneumoniae isolates which were recovered from the same stool sample displayed identical resistance patterns. Agarose gel electrophoresis revealed that S. typhi and laboratory-derived transconjugants contained a high-molecular-weight plasmid present in the resistant intestinal bacteria.

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