Enhancing Long-term Weight Loss Maintenance: 2 Year Results from the Keep It Off Randomized Controlled Trial

Overview

Journal Prev Med

Specialty Public Health

Date 2013 Jan 2

PMID 23276775

Citations 32

Authors

Nancy E Sherwood

A Lauren Crain

Brian C Martinson

Christopher P Anderson

Marcia G Hayes

Julie D Anderson

Meghan M Senso

Robert W Jeffery

Affiliations

Soon will be listed here.

Abstract

Objective: The Keep It Off trial evaluated the efficacy of a phone-based weight loss maintenance intervention among adults who had recently lost weight in Minnesota (2007-2010).

Methods: 419 adults who had recently lost ≥ 10% of their body weight were randomized to the "Guided" or "Self-Directed" intervention. Guided participants received a 10 session workbook, 10 biweekly, eight monthly and six bimonthly phone coaching calls, bimonthly weight graphs and tailored letters based on self-reported weights. Self-Directed participants received the workbook and two calls. Primary outcomes are weight change and maintenance (regain of <2.5% of baseline body weight).

Results: Mixed model repeated-measures analysis examining weight change revealed a significant time by treatment group interaction (p<0.0085). Guided participants regained significantly less weight than the Self-Directed participants at 12 and 24 months. The odds of 24 month maintenance were 1.37 (95% CI: 0.97-2.03) times greater in the Guided than in the Self-Directed group. When maintenance rates were compared across all follow-ups, there was a consistently higher maintenance rate for Guided participants (HR 1.31, 95% CI: 1.12-1.54).

Conclusions: A sustained, supportive phone- and mail-based intervention promotes weight loss maintenance relative to a brief intervention for participants who have recently lost weight.

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