Quantification of IgM and IgA Anti-pneumococcal Capsular Polysaccharides by a New ELISA Assay: a Valuable Diagnostic and Prognostic Tool for Common Variable Immunodeficiency

Overview

Journal J Clin Immunol

Publisher Springer

Specialty Allergy & Immunology

Date 2013 Jan 1

PMID 23274802

Citations 19

Authors

F M Cavaliere

C Milito

H Martini

M Schlesier

R Drager

K Schutz

G Brunetti

A M Pesce

V Thon

K Warnatz

I Quinti

Affiliations

Soon will be listed here.

Abstract

Purpose: Existing ways of assessing CVID patients at risk of pulmonary infections are not universally accepted. The need to identify additional prognostic factors allowed us to evaluate the anti-polysaccharide IgA and IgM responses in 125 CVID patients immunized with the 23-valent pneumococcal polysaccharide (PS) vaccine (Pneumovax(®)).

Methods: We used a new anti-PS23 IgM and IgA ELISA assay, which evaluates a global response to all 23 polysaccharides contained in Pneumovax(®).

Results: Anti-PS23 IgM and/or IgA antibodies were detectable in a minority of CVID patients. Antibody responses were correlated to B cell subpopulations and serum immunoglobulin concentrations. The non responders had a higher incidence of pneumonia and bronchiectasis and responders had the lowest incidence of respiratory complications.

Conclusions: This new ELISA assay allows for studying vaccine response in patients on Ig replacement therapy. This test also is an additional method of evaluation of specific antibody responses representing a valuable contribution to identify prognostic marker in CVID patients.

Citing Articles

Monogenic Inborn Errors of Immunity with impaired IgG response to polysaccharide antigens but normal IgG levels and normal IgG response to protein antigens.

Fasshauer M, Dinges S, Staudacher O, Voller M, Stittrich A, von Bernuth H Front Pediatr. 2024; 12:1386959.

PMID: 38933494 PMC: 11203071. DOI: 10.3389/fped.2024.1386959.

A Systematic Review of the Clinical Diagnosis of Transient Hypogammaglobulinemia of Infancy.

Justiz-Vaillant A, Hoyte T, Davis N, Deonarinesingh C, De Silva A, Dhanpaul D Children (Basel). 2023; 10(8).

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Functional CVIDs phenotype clusters identified by the integration of immune parameters after BNT162b2 boosters.

Piano Mortari E, Pulvirenti F, Marcellini V, Terreri S, Salinas A, Ferrari S Front Immunol. 2023; 14:1194225.

PMID: 37304298 PMC: 10248522. DOI: 10.3389/fimmu.2023.1194225.

Antibody responses after sequential vaccination with PCV13 and PPSV23 in kidney transplant recipients.

Mulling N, van de Sand L, Volk K, Aufderhorst U, van der Linden M, Horn P Infection. 2023; 51(6):1703-1716.

PMID: 37243960 PMC: 10665231. DOI: 10.1007/s15010-023-02054-3.

IgG antibody response to pneumococcal-conjugated vaccine (Prevenar®13) in children with immunodeficiency disorders.

Garrido-Jareno M, Sahuquillo-Arce J, Rodriguez-Vega H, Lloret-Sos C, Gil-Brusola A, Lopez-Hontangas J Med Microbiol Immunol. 2023; 212(1):93-102.

PMID: 36595027 DOI: 10.1007/s00430-022-00759-0.

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