Polymorphism in Vitamin D Receptor and Osteoprotegerin Genes in Egyptian Rheumatoid Arthritis Patients with and Without Osteoporosis

Overview

Journal Mol Biol Rep

Specialty Molecular Biology

Date 2012 Dec 29

PMID 23271131

Citations 21

Authors

Yousry Mostafa Hussien

Amal Shehata

Rehab A Karam

Saad S Alzahrani

Hanem Magdy

Abeer M El-Shafey

Affiliations

Soon will be listed here.

Abstract

1α,25-Dihydroxyvitamin D3 upregulates the expression of the receptor activator of nuclear factor kB ligand (RANKL), and downregulates osteoprotegerin (OPG) expression. We tested the effects of polymorphisms in the vitamin D receptor gene (VDR), and OPG gene in rheumatoid arthritis (RA) patients and healthy controls and their relationship to bone mineral density (BMD) and development of osteoporosis. Three hundred and fifty women were evaluated, 200 women having RA and 150 healthy control. The subjects were genotyped for polymorphism at BsmI in VDR and A163G in OPG genes by polymerase chain reaction followed by restriction fragment length polymorphism analysis. BMD was also measured. In A163G, the G allele increased the risk for RA and for the development of osteoporosis. We found a significant association between lower hip (BMD-h) and genotype variants of VDR (BsmI) and OPG A163G in RA patients with osteoporosis. Our results suggested that OPG A163G polymorphism was associated with RA susceptibility and with the development of osteoporosis in these patients. Also, VDR and OPG genes are important candidates for osteoporosis in RA patients.

Citing Articles

The impact of genetic variants related to vitamin D and autoimmunity: A systematic review.

Trefilio L, Bottino L, de Carvalho Cardoso R, Montes G, Fontes-Dantas F Heliyon. 2024; 10(7):e27700.

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Osteoprotegerin Gene as a Biomarker in the Development of Osteoporosis in Postmenopausal Women.

Przerwa F, Uzar I, Bogacz A, Kotrych K, Sulikowski T, Wolek M Biomedicines. 2023; 11(12).

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Association between polymorphisms and osteoporosis risk: An updated meta-analysis.

Han X, Zheng L, Mu Y, Li H, He X Front Genet. 2022; 13:1032110.

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Associations of osteoprotegerin (OPG) TNFRSF11B gene polymorphisms with risk of fractures in older adult populations: meta-analysis of genetic and genome-wide association studies.

Tharabenjasin P, Pabalan N, Jarjanazi H, Jinawath N Osteoporos Int. 2021; 33(3):563-575.

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Genetic and expression deregulation of immunoregulatory genes in rheumatoid arthritis.

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