Vitamin D Level Between Calcium-Phosphorus Homeostasis and Immune System: New Perspective in Osteoporosis

Overview

Journal Curr Osteoporos Rep

Publisher Current Science

Specialties Endocrinology
Orthopedics

Date 2016 Oct 14

PMID 27734322

Citations 20

Authors

Daniele Bellavia

Viviana Costa

Angela De Luca

Melania Maglio

Stefania Pagani

Milena Fini

Gianluca Giavaresi

Affiliations

Soon will be listed here.

Abstract

Vitamin D is a key molecule in calcium and phosphate homeostasis; however, increasing evidence has recently shown that it also plays a crucial role in the immune system, both innate and adaptive. A deregulation of vitamin D levels, due also to mutations and polymorphisms in the genes of the vitamin D pathway, determines severe alterations in the homeostasis of the organism, resulting in a higher risk of onset of some diseases, including osteoporosis. This review gives an overview of the influence of vitamin D levels on the pathogenesis of osteoporosis, between bone homeostasis and immune system.

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References

van den Bergh J, van Geel T, Geusens P . Osteoporosis, frailty and fracture: implications for case finding and therapy. Nat Rev Rheumatol. 2012; 8(3):163-72. DOI: 10.1038/nrrheum.2011.217. View

Engelke K, Gluer C . Quality and performance measures in bone densitometry: part 1: errors and diagnosis. Osteoporos Int. 2006; 17(9):1283-92. DOI: 10.1007/s00198-005-0039-0. View

Gluer C, Lu Y, Engelke K . Quality and performance measures in bone densitometry. Part 2: fracture risk. Osteoporos Int. 2006; 17(10):1449-58. DOI: 10.1007/s00198-005-0038-1. View

Blake G, Fogelman I . Role of dual-energy X-ray absorptiometry in the diagnosis and treatment of osteoporosis. J Clin Densitom. 2007; 10(1):102-10. DOI: 10.1016/j.jocd.2006.11.001. View

Kanis J, McCloskey E, Johansson H, Cooper C, Rizzoli R, Reginster J . European guidance for the diagnosis and management of osteoporosis in postmenopausal women. Osteoporos Int. 2012; 24(1):23-57. PMC: 3587294. DOI: 10.1007/s00198-012-2074-y. View

Cosman F, de Beur S, LeBoff M, Lewiecki E, Tanner B, Randall S . Clinician's Guide to Prevention and Treatment of Osteoporosis. Osteoporos Int. 2014; 25(10):2359-81. PMC: 4176573. DOI: 10.1007/s00198-014-2794-2. View

Lentle B, Cheung A, Hanley D, Leslie W, Lyons D, Papaioannou A . Osteoporosis Canada 2010 guidelines for the assessment of fracture risk. Can Assoc Radiol J. 2011; 62(4):243-50. PMC: 5101067. DOI: 10.1016/j.carj.2011.05.001. View

Al-Saleh Y, Sulimani R, Sabico S, Raef H, Fouda M, Alshahrani F . 2015 Guidelines for Osteoporosis in Saudi Arabia: Recommendations from the Saudi Osteoporosis Society. Ann Saudi Med. 2015; 35(1):1-12. PMC: 6152549. DOI: 10.5144/0256-4947.2015.1. View

Maalouf G, Gannage-Yared M, Ezzedine J, Larijani B, Badawi S, Rached A . Middle East and North Africa consensus on osteoporosis. J Musculoskelet Neuronal Interact. 2007; 7(2):131-43. View

10.

Pecina J, Romanovsky L, Merry S, Kennel K, Thacher T . Comparison of Clinical Risk Tools for Predicting Osteoporosis in Women Ages 50-64. J Am Board Fam Med. 2016; 29(2):233-9. DOI: 10.3122/jabfm.2016.02.150237. View

11.

Delmas P, Eastell R, Garnero P, Seibel M, Stepan J . The use of biochemical markers of bone turnover in osteoporosis. Committee of Scientific Advisors of the International Osteoporosis Foundation. Osteoporos Int. 2001; 11 Suppl 6:S2-17. DOI: 10.1007/s001980070002. View

12.

Johnell O, Oden A, De Laet C, Garnero P, Delmas P, Kanis J . Biochemical indices of bone turnover and the assessment of fracture probability. Osteoporos Int. 2002; 13(7):523-6. DOI: 10.1007/s001980200068. View

13.

Adami S, Bertoldo F, Brandi M, Cepollaro C, Filipponi P, Fiore E . [Guidelines for the diagnosis, prevention and treatment of osteoporosis]. Reumatismo. 2010; 61(4):260-84. DOI: 10.4081/reumatismo.2009.260. View

14.

Nordin B, Morris H . Osteoporosis and vitamin D. J Cell Biochem. 1992; 49(1):19-25. DOI: 10.1002/jcb.240490105. View

15.

Richy F, Schacht E, Bruyere O, Ethgen O, Gourlay M, Reginster J . Vitamin D analogs versus native vitamin D in preventing bone loss and osteoporosis-related fractures: a comparative meta-analysis. Calcif Tissue Int. 2005; 76(3):176-86. DOI: 10.1007/s00223-004-0005-4. View

16.

Strom O, Borgstrom F, Kanis J, Compston J, Cooper C, McCloskey E . Osteoporosis: burden, health care provision and opportunities in the EU: a report prepared in collaboration with the International Osteoporosis Foundation (IOF) and the European Federation of Pharmaceutical Industry Associations (EFPIA). Arch Osteoporos. 2012; 6:59-155. DOI: 10.1007/s11657-011-0060-1. View

17.

Weaver C, Alexander D, Boushey C, Dawson-Hughes B, Lappe J, LeBoff M . Calcium plus vitamin D supplementation and risk of fractures: an updated meta-analysis from the National Osteoporosis Foundation. Osteoporos Int. 2015; 27(1):367-76. PMC: 4715837. DOI: 10.1007/s00198-015-3386-5. View

18.

Brannon P, Yetley E, Bailey R, Picciano M . Overview of the conference "Vitamin D and Health in the 21st Century: an Update". Am J Clin Nutr. 2008; 88(2):483S-490S. DOI: 10.1093/ajcn/88.2.483S. View

19.

Wobke T, Sorg B, Steinhilber D . Vitamin D in inflammatory diseases. Front Physiol. 2014; 5:244. PMC: 4078458. DOI: 10.3389/fphys.2014.00244. View

20.

Lagishetty V, Liu N, Hewison M . Vitamin D metabolism and innate immunity. Mol Cell Endocrinol. 2011; 347(1-2):97-105. PMC: 3200473. DOI: 10.1016/j.mce.2011.04.015. View