Therapeutic Potential of Autologous Stem Cell Transplantation for Cerebral Palsy

Overview

Journal Case Rep Transplant

Publisher Wiley

Specialty General Surgery

Date 2012 Dec 22

PMID 23259143

Citations 19

Authors

Chaitanya Purandare

D G Shitole

Vaijayantee Belle

Aarti Kedari

Neeta Bora

Meghnad Joshi

Affiliations

Soon will be listed here.

Abstract

Background. Cerebral palsy (CP) is a severe disabling disease with worldwide incidence being 2 to 3 per 1000 live births. CP was considered as a noncurable, nonreparative disorder, but stem cell therapy offers a potential treatment for CP. Objective. The present study evaluates the safety and efficacy of autologous bone-marrow-derived mononuclear cell (BMMNCs) transplantation in CP patient. Material and Methods. In the present study, five infusions of autologous stem cells were injected intrathecally. Changes in neurological deficits and improvements in function were assessed using Gross Motor Function Classification System (GMFCS-E&R) scale. Results. Significant motor, sensory, cognitive, and speech improvements were observed. Bowel and bladder control has been achieved. On the GMFCS-E&R level, the patient was promoted from grade III to I. Conclusion. In this study, we report that intrathecal infusion of autologous BMMNCs seems to be feasible, effective, and safe with encouraging functional outcome improvements in CP patient.

Citing Articles

A systematic review of cell therapy modalities and outcomes in cerebral palsy.

Akat A, Karaoz E Mol Cell Biochem. 2024; 480(2):891-922.

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The density of bone marrow mononuclear cells and CD34+ cells in patients with three neurologic conditions.

Nguyen K, Hoang N, Nguyen H, Thanh L BMC Neurol. 2023; 23(1):37.

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Are We Getting It Right? A Scoping Review of Outcomes Reported in Cell Therapy Clinical Studies for Cerebral Palsy.

Finch-Edmondson M, Paton M, Honan I, Karlsson P, Stephenson C, Chiu D J Clin Med. 2022; 11(24).

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The safety and efficacy of umbilical cord blood mononuclear cells in individuals with spastic cerebral palsy: a randomized double-blind sham-controlled clinical trial.

Zarrabi M, Ghahvechi Akbari M, Amanat M, Majmaa A, Moaiedi A, Montazerlotfelahi H BMC Neurol. 2022; 22(1):123.

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Therapeutic effects of stem cells in different body systems, a novel method that is yet to gain trust: A comprehensive review.

Ebrahimi A, Ahmadi H, Pourfraidon Ghasrodashti Z, Tanide N, Shahriarirad R, Erfani A Bosn J Basic Med Sci. 2021; 21(6):672-701.

PMID: 34255619 PMC: 8554700. DOI: 10.17305/bjbms.2021.5508.

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