Noncontact Measurement of Elasticity for the Detection of Soft-tissue Tumors Using Phase-sensitive Optical Coherence Tomography Combined with a Focused Air-puff System

Overview

Journal Opt Lett

Specialty Ophthalmology

Date 2012 Dec 22

PMID 23258046

Citations 40

Authors

Shang Wang

Jiasong Li

Ravi Kiran Manapuram

Floredes M Menodiado

Davis R Ingram

Michael D Twa

Alexander J Lazar

Dina C Lev

Raphael E Pollock

Kirill V Larin

Affiliations

Soon will be listed here.

Abstract

We report on an optical noncontact method for the detection of soft-tissue tumors based on the measurement of their elasticity. A focused air-puff system is used to excite surface waves (SWs) on soft tissues with transient static pressure. A high-speed phase-sensitive optical coherence tomography system is used to measure the SWs as they propagate from the point of excitation. To evaluate the stiffness of soft tissues, the Young's modulus is quantified based on the group velocity of SWs. Pilot experiments were performed on ex vivo human myxoma and normal fat. Results demonstrate the feasibility of the proposed method to measure elasticity and differentiate soft-tissue tumors from normal tissues.

Citing Articles

corneal elastography: A topical review of challenges and opportunities.

Lan G, Twa M, Song C, Feng J, Huang Y, Xu J Comput Struct Biotechnol J. 2023; 21:2664-2687.

PMID: 37181662 PMC: 10173410. DOI: 10.1016/j.csbj.2023.04.009.

Nonlinear Elasticity Assessment with Optical Coherence Elastography for High-Selectivity Differentiation of Breast Cancer Tissues.

Gubarkova E, Sovetsky A, Matveev L, Matveyev A, Vorontsov D, Plekhanov A Materials (Basel). 2022; 15(9).

PMID: 35591642 PMC: 9099511. DOI: 10.3390/ma15093308.

Wave-based optical coherence elastography: The 10-year perspective.

Zvietcovich F, Larin K Prog Biomed Eng (Bristol). 2022; 4(1).

PMID: 35187403 PMC: 8856668. DOI: 10.1088/2516-1091/ac4512.

High resolution optical coherence elastography of retina under prosthetic electrode.

Li R, Du Z, Qian X, Li Y, Martinez-Camarillo J, Jiang L Quant Imaging Med Surg. 2021; 11(3):918-927.

PMID: 33654665 PMC: 7829169. DOI: 10.21037/qims-20-1137.

Confocal air-coupled ultrasonic optical coherence elastography probe for quantitative biomechanics.

Zvietcovich F, Nair A, Ambekar Y, Singh M, Aglyamov S, Twa M Opt Lett. 2020; 45(23):6567-6570.

PMID: 33258863 PMC: 10041740. DOI: 10.1364/OL.410593.

References

Samani A, Bishop J, Luginbuhl C, Plewes D . Measuring the elastic modulus of ex vivo small tissue samples. Phys Med Biol. 2003; 48(14):2183-98. DOI: 10.1088/0031-9155/48/14/310. View

Li C, Huang Z, Wang R . Elastic properties of soft tissue-mimicking phantoms assessed by combined use of laser ultrasonics and low coherence interferometry. Opt Express. 2011; 19(11):10153-63. DOI: 10.1364/OE.19.010153. View

Sinkus R, Lorenzen J, Schrader D, Lorenzen M, Dargatz M, Holz D . High-resolution tensor MR elastography for breast tumour detection. Phys Med Biol. 2000; 45(6):1649-64. DOI: 10.1088/0031-9155/45/6/317. View

Li C, Guan G, Huang Z, Johnstone M, Wang R . Noncontact all-optical measurement of corneal elasticity. Opt Lett. 2012; 37(10):1625-7. DOI: 10.1364/OL.37.001625. View

Butcher D, Alliston T, Weaver V . A tense situation: forcing tumour progression. Nat Rev Cancer. 2009; 9(2):108-22. PMC: 2649117. DOI: 10.1038/nrc2544. View

Paszek M, Zahir N, Johnson K, Lakins J, Rozenberg G, Gefen A . Tensional homeostasis and the malignant phenotype. Cancer Cell. 2005; 8(3):241-54. DOI: 10.1016/j.ccr.2005.08.010. View

Boppart S, Luo W, Marks D, Singletary K . Optical coherence tomography: feasibility for basic research and image-guided surgery of breast cancer. Breast Cancer Res Treat. 2004; 84(2):85-97. DOI: 10.1023/B:BREA.0000018401.13609.54. View

Singer S, Antonescu C, Riedel E, Brennan M . Histologic subtype and margin of resection predict pattern of recurrence and survival for retroperitoneal liposarcoma. Ann Surg. 2003; 238(3):358-70. PMC: 1422708. DOI: 10.1097/01.sla.0000086542.11899.38. View

Liang X, Oldenburg A, Crecea V, Chaney E, Boppart S . Optical micro-scale mapping of dynamic biomechanical tissue properties. Opt Express. 2008; 16(15):11052-65. PMC: 2883328. DOI: 10.1364/oe.16.011052. View

10.

Liang X, Orescanin M, Toohey K, Insana M, Boppart S . Acoustomotive optical coherence elastography for measuring material mechanical properties. Opt Lett. 2009; 34(19):2894-6. PMC: 2883315. DOI: 10.1364/OL.34.002894. View

11.

Samani A, Zubovits J, Plewes D . Elastic moduli of normal and pathological human breast tissues: an inversion-technique-based investigation of 169 samples. Phys Med Biol. 2007; 52(6):1565-76. DOI: 10.1088/0031-9155/52/6/002. View

12.

Nightingale K, McAleavey S, Trahey G . Shear-wave generation using acoustic radiation force: in vivo and ex vivo results. Ultrasound Med Biol. 2003; 29(12):1715-23. DOI: 10.1016/j.ultrasmedbio.2003.08.008. View

13.

Li C, Guan G, Cheng X, Huang Z, Wang R . Quantitative elastography provided by surface acoustic waves measured by phase-sensitive optical coherence tomography. Opt Lett. 2012; 37(4):722-4. DOI: 10.1364/OL.37.000722. View