Autocrine Functions of VEGF in Breast Tumor Cells: Adhesion, Survival, Migration and Invasion

Overview

Journal Cell Adh Migr

Specialty Cell Biology

Date 2012 Dec 22

PMID 23257828

Citations 75

Authors

Martine Perrot-Applanat

Melanie Di Benedetto

Affiliations

Soon will be listed here.

Abstract

Vascular endothelial growth factor A (VEGF-A) is well known for its key roles in blood vessel growth. Although most studies on VEGF and VEGF receptors have been focused on their functions in angiogenesis and in endothelial cells, the role of VEGF in cancer biology appears as an emerging area of importance. In this context, the presence of VEGF receptors in tumor cells strongly suggests that VEGF-A also promotes a wide range of functions, both in vitro and in vivo, all autocrine functions on tumor cells, including adhesion, survival, migration and invasion. Ultimately, refining our knowledge of VEGF signaling pathways in tumor cells should help us to understand why the current used treatments targeting the VEGF pathway in cancer are not universally effective in inhibiting metastasis tumors, and it should also provide new avenues for future therapies.

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