» Articles » PMID: 23256522

Antifungal Properties of Durancins Isolated from Enterococcus Durans A5-11 and of Its Synthetic Fragments

Overview
Specialty Microbiology
Date 2012 Dec 22
PMID 23256522
Citations 12
Authors
Affiliations
Soon will be listed here.
Abstract

The aim of this work was to study the antifungal properties of durancins isolated from Enterococcus durans A5-11 and of their chemically synthesized fragments. Enterococcus durans A5-11 is a lactic acid bacteria strain isolated from traditional Mongolian airag cheese. This strain inhibits the growth of several fungi including Fusarium culmorum, Penicillium roqueforti and Debaryomyces hansenii. It produces two bacteriocins: durancin A5-11a and durancin A5-11b, which have similar antimicrobial properties. The whole durancins A5-11a and A5-11b, as well as their N- and C-terminal fragments were synthesized, and their antifungal properties were studied. C-terminal fragments of both durancins showed stronger antifungal activities than other tested peptides. Treatment of D. hansenii LMSA2.11.003 strain with 2 mmol l(-1) of the synthetic peptides led to the loss of the membrane integrity and to several changes in the ultra-structure of the yeast cells. Chemically synthesized durancins and their synthetic fragments showed different antimicrobial properties from each other. N-terminal peptides show activities against both bacterial and fungal strains tested. C-terminal peptides have specific activities against tested fungal strain and do not show antibacterial activity. However, the C-terminal fragment enhances the activity of the N-terminal fragment in the whole bacteriocins against bacteria.

Citing Articles

Limosilactobacillus reuteri as sustainable biological control agent against toxigenic Fusarium verticillioides.

Hirozawa M, Ono M, de Souza Suguiura I, Garcia S, Bordini J, Amador I Braz J Microbiol. 2023; 54(3):2219-2226.

PMID: 37531006 PMC: 10484862. DOI: 10.1007/s42770-023-01081-4.


Antifungal metabolites, their novel sources, and targets to combat drug resistance.

Choudhary M, Kumar V, Naik B, Verma A, Saris P, Kumar V Front Microbiol. 2022; 13:1061603.

PMID: 36532457 PMC: 9755354. DOI: 10.3389/fmicb.2022.1061603.


Antifungal Peptides and Proteins to Control Toxigenic Fungi and Mycotoxin Biosynthesis.

Martinez-Culebras P, Gandia M, Garrigues S, Marcos J, Manzanares P Int J Mol Sci. 2021; 22(24).

PMID: 34948059 PMC: 8703302. DOI: 10.3390/ijms222413261.


Current Knowledge of the Mode of Action and Immunity Mechanisms of LAB-Bacteriocins.

Perez-Ramos A, Madi-Moussa D, Coucheney F, Drider D Microorganisms. 2021; 9(10).

PMID: 34683428 PMC: 8538875. DOI: 10.3390/microorganisms9102107.


Isolation and Characterization of Lactic Acid Bacteria and Yeasts from Typical Bulgarian Sourdoughs.

Petkova M, Stefanova P, Gotcheva V, Angelov A Microorganisms. 2021; 9(7).

PMID: 34206198 PMC: 8306846. DOI: 10.3390/microorganisms9071346.