Cognitive Dysfunction with Aging and the Role of Inflammation

Overview

Journal Ther Adv Chronic Dis

Publisher Sage Publications

Date 2012 Dec 20

PMID 23251749

Citations 93

Authors

Arthur A Simen

Kelly A Bordner

Mark P Martin

Lawrence A Moy

Lisa C Barry

Affiliations

Soon will be listed here.

Abstract

As the average lifespan continues to climb because of advances in medical care, there is a greater need to understand the factors that contribute to quality of life in the elderly. The capacity to live independently is highly significant in this regard, but is compromised by cognitive dysfunction. Aging is associated with decreases in cognitive function, including impairments in episodic memory and executive functioning. The prefrontal cortex appears to be particularly vulnerable to the effects of advancing age. Although the mechanism of age-related cognitive decline is not yet known, age-related inflammatory changes are likely to play a role. New insights from preclinical and clinical research may give rise to novel therapeutics which may have efficacy in slowing or preventing cognitive decline with advancing age.

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References

van Gassen K, Netzeband J, De Graan P, Gruol D . The chemokine CCL2 modulates Ca2+ dynamics and electrophysiological properties of cultured cerebellar Purkinje neurons. Eur J Neurosci. 2005; 21(11):2949-57. DOI: 10.1111/j.1460-9568.2005.04113.x. View

Gundlah C, Kohama S, Mirkes S, Garyfallou V, Urbanski H, Bethea C . Distribution of estrogen receptor beta (ERbeta) mRNA in hypothalamus, midbrain and temporal lobe of spayed macaque: continued expression with hormone replacement. Brain Res Mol Brain Res. 2000; 76(2):191-204. DOI: 10.1016/s0006-8993(99)02475-0. View

Colman R, Anderson R, Johnson S, Kastman E, Kosmatka K, Beasley T . Caloric restriction delays disease onset and mortality in rhesus monkeys. Science. 2009; 325(5937):201-4. PMC: 2812811. DOI: 10.1126/science.1173635. View

Tracy R, Lemaitre R, Psaty B, Ives D, Evans R, Cushman M . Relationship of C-reactive protein to risk of cardiovascular disease in the elderly. Results from the Cardiovascular Health Study and the Rural Health Promotion Project. Arterioscler Thromb Vasc Biol. 1997; 17(6):1121-7. DOI: 10.1161/01.atv.17.6.1121. View

Meyers C, Albitar M, Estey E . Cognitive impairment, fatigue, and cytokine levels in patients with acute myelogenous leukemia or myelodysplastic syndrome. Cancer. 2005; 104(4):788-93. DOI: 10.1002/cncr.21234. View

Swindell W . Genes and gene expression modules associated with caloric restriction and aging in the laboratory mouse. BMC Genomics. 2009; 10:585. PMC: 2795771. DOI: 10.1186/1471-2164-10-585. View

Yogev-Seligmann G, Hausdorff J, Giladi N . The role of executive function and attention in gait. Mov Disord. 2007; 23(3):329-42. PMC: 2535903. DOI: 10.1002/mds.21720. View

Tulving E . Multiple memory systems and consciousness. Hum Neurobiol. 1987; 6(2):67-80. View

Pietschmann P, Gollob E, Brosch S, Hahn P, Kudlacek S, Willheim M . The effect of age and gender on cytokine production by human peripheral blood mononuclear cells and markers of bone metabolism. Exp Gerontol. 2003; 38(10):1119-27. DOI: 10.1016/s0531-5565(03)00189-x. View

10.

Nilsson L . Memory function in normal aging. Acta Neurol Scand Suppl. 2003; 179:7-13. DOI: 10.1034/j.1600-0404.107.s179.5.x. View

11.

Godbout J, Chen J, Abraham J, Richwine A, Berg B, Kelley K . Exaggerated neuroinflammation and sickness behavior in aged mice following activation of the peripheral innate immune system. FASEB J. 2005; 19(10):1329-31. DOI: 10.1096/fj.05-3776fje. View

12.

Hughes Z, Liu F, Marquis K, Muniz L, Pangalos M, Ring R . Estrogen receptor neurobiology and its potential for translation into broad spectrum therapeutics for CNS disorders. Curr Mol Pharmacol. 2009; 2(3):215-36. DOI: 10.2174/1874467210902030215. View

13.

Li W, Li W, Yao Y, Zhang W, Yin Y, Wu G . Glucocorticoids increase impairments in learning and memory due to elevated amyloid precursor protein expression and neuronal apoptosis in 12-month old mice. Eur J Pharmacol. 2009; 628(1-3):108-15. DOI: 10.1016/j.ejphar.2009.11.045. View

14.

Halliday G, Robinson S, Shepherd C, Kril J . Alzheimer's disease and inflammation: a review of cellular and therapeutic mechanisms. Clin Exp Pharmacol Physiol. 2000; 27(1-2):1-8. DOI: 10.1046/j.1440-1681.2000.03200.x. View

15.

Miller K, Streit W . The effects of aging, injury and disease on microglial function: a case for cellular senescence. Neuron Glia Biol. 2008; 3(3):245-53. DOI: 10.1017/S1740925X08000136. View

16.

Bremmer M, Beekman A, Deeg D, Penninx B, Dik M, Hack C . Inflammatory markers in late-life depression: results from a population-based study. J Affect Disord. 2007; 106(3):249-55. DOI: 10.1016/j.jad.2007.07.002. View

17.

Stuck A, Walthert J, Nikolaus T, Bula C, Hohmann C, Beck J . Risk factors for functional status decline in community-living elderly people: a systematic literature review. Soc Sci Med. 1999; 48(4):445-69. DOI: 10.1016/s0277-9536(98)00370-0. View

18.

Trompet S, de Craen A, Slagboom P, Shepherd J, Blauw G, Murphy M . Genetic variation in the interleukin-1 beta-converting enzyme associates with cognitive function. The PROSPER study. Brain. 2008; 131(Pt 4):1069-77. DOI: 10.1093/brain/awn023. View

19.

Tan M, Chua W, Esiri M, Smith A, Vinters H, Lai M . Genome wide profiling of altered gene expression in the neocortex of Alzheimer's disease. J Neurosci Res. 2009; 88(6):1157-69. DOI: 10.1002/jnr.22290. View

20.

Stebbins G, Carrillo M, Dorfman J, Dirksen C, Desmond J, Turner D . Aging effects on memory encoding in the frontal lobes. Psychol Aging. 2002; 17(1):44-55. DOI: 10.1037//0882-7974.17.1.44. View