A New Dynamic Model of Three Cell Interactions for CTL Responses

Overview

Journal Oncoimmunology

Specialty Allergy & Immunology

Date 2012 Dec 18

PMID 23243618

Citations 3

Authors

Khawaja Ashfaque Ahmed

Lu Wang

Jim Xiang

Affiliations

Soon will be listed here.

Abstract

The exact mechanisms of CD4 help in the generation of memory cytotoxic T lymphocytes (CTLs) remain largely illusive. We propose that dendritic cells (DCs) first interact with CD4(+) T cells, resulting in DC licensing and CD4(+) T-cell priming. Thereafter, CD8(+) T cells can receive stimulatory signals from DC-CD4(+) T-cell clusters and as well as individually from licensed DCs and primed CD4(+) T cells.

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