Evaluation of Ovarian and Testicular Tissue Cryopreservation in Children Undergoing Gonadotoxic Therapies

Overview

Journal J Assist Reprod Genet

Publisher Springer

Specialties Genetics
Reproductive Medicine

Date 2012 Dec 18

PMID 23242649

Citations 13

Authors

Samir N Babayev

Erol Arslan

Stanley Kogan

Fred Moy

Kutluk Oktay

Affiliations

Soon will be listed here.

Abstract

Objective: Ovarian and testicular tissue cryopreservation are the only fertility preservation options for sexually immature individuals. Because of their experimental nature, it is important to determine safety and possible bundling with other medicallyindicated procedures.

Study Design: Prospective observational.

Results: Cryopreservation indications included cancer in 75 % of females and 50 % of males, while non-cancer indications included various hematological conditions. Similar numbers of females (12/28) and males (3/9) underwent prior chemotherapy. Females underwent laparoscopic (27/28) or robotic (1/28) approaches while incisional biopsy was used in males. Bundling of ovarian and testicular harvesting with other medicallyindicated procedures was performed in 42 % and 22 %, respectively. The operative time inclusive of bundled procedures was similar (1.6 ± 0.1 vs. 0.9 ± 0.3 h) but the discharge time was significantly longer for females than males (10.4 ± 0.6 vs. 4.6 ± 0.6 h, p<0.05) due to frequent bundling of medically-indicated procedures in females. All procedures were successfully completed without complications or significant blood loss.

Conclusions: Pediatric gonadal tissue cryopreservation can be combined with other medically-indicated procedures to minimize the potential inconvenience, additional anesthetic risks, and costs.

Citing Articles

Trends in fertility preservation treatments in Japan until 2023: analysis of the Japan Oncofertility Registry.

Kawai T, Harada M, Urata Y, Sanada Y, Kaneda Y, Takai Y Int J Clin Oncol. 2025; .

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Ovarian Tissue Cryopreservation versus Other Fertility Techniques for Chemoradiation-Induced Premature Ovarian Insufficiency in Women: A Systematic Review and Future Directions.

Chaudhri E, Salman A, Awartani K, Khan Z, Hashmi S Life (Basel). 2024; 14(3).

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A 16-year bicentric retrospective analysis of ovarian tissue cryopreservation in pediatric units: indications, results, and outcome.

Grellet-Grun M, Delepine B, Van Quyen P, Averous G, Durlach A, Greze C Front Endocrinol (Lausanne). 2023; 14:1158405.

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Spermatogonial Stem Cell-Based Therapies: Taking Preclinical Research to the Next Level.

Sanou I, van Maaren J, Eliveld J, Lei Q, Meissner A, de Melker A Front Endocrinol (Lausanne). 2022; 13:850219.

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Fertility preservation in boys: recent developments and new insights .

Goossens E, Jahnukainen K, Mitchell R, van Pelt A, Pennings G, Rives N Hum Reprod Open. 2020; 2020(3):hoaa016.

PMID: 32529047 PMC: 7275639. DOI: 10.1093/hropen/hoaa016.

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