Dietary Restriction and Mitochondrial Function Link Replicative and Chronological Aging in Saccharomyces Cerevisiae

Overview

Journal Exp Gerontol

Specialty Geriatrics

Date 2012 Dec 14

PMID 23235143

Citations 41

Authors

Joe R Delaney

Christopher Murakami

Annie Chou

Daniel Carr

Jennifer Schleit

George L Sutphin

Elroy H An

Anthony S Castanza

Marissa Fletcher

Sarani Goswami

Sean Higgins

Mollie Holmberg

Jessica Hui

Monika Jelic

Ki-Soo Jeong

Jin R Kim

Shannon Klum

Eric Liao

Michael S Lin

Winston Lo

Hillary Miller

Richard Moller

Zhao J Peng

Tom Pollard

Prarthana Pradeep

Dillon Pruett

Dilreet Rai

Vanessa Ros

Alex Schuster

Minnie Singh

Benjamin L Spector

Helen Vander Wende

Adrienne M Wang

Brian M Wasko

Brady Olsen

Matt Kaeberlein

Affiliations

Soon will be listed here.

Abstract

Chronological aging of budding yeast cells results in a reduction in subsequent replicative life span through unknown mechanisms. Here we show that dietary restriction during chronological aging delays the reduction in subsequent replicative life span up to at least 23days of chronological age. We further show that among the viable portion of the control population aged 26days, individual cells with the lowest mitochondrial membrane potential have the longest subsequent replicative lifespan. These observations demonstrate that dietary restriction modulates a common molecular mechanism linking chronological and replicative aging in yeast and indicate a critical role for mitochondrial function in this process.

Citing Articles

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