Expression and Phosphorylation of Stathmin Correlate with Cell Migration in Esophageal Squamous Cell Carcinoma

Overview

Journal Oncol Rep

Specialty Oncology

Date 2012 Dec 12

PMID 23229199

Citations 23

Authors

Fei Liu

Yu-Lin Sun

Yang Xu

Fang Liu

Li-Shun Wang

Xiao-Hang Zhao

Affiliations

Soon will be listed here.

Abstract

Microtubules play extensive roles in cellular processes, including cell motility. Stathmin is an important protein which destabilizes microtubules. The essential function of stathmin is closely associated with its phosphorylation status. Stathmin is overexpressed in many human cancers and has a significant relationship with clinical characteristics such as grade, tumor size and prognosis. We demonstrated that stathmin was overexpressed in ESCC tissues using both 2-DE and immunohistochemistry analysis. In addition, overexpression of stathmin was significantly correlated with histological grade in ESCC. However, no correlation was found with age, gender and lymph node metastasis. Knockdown of stathmin with siRNA impaired cell migration in KYSE30 and KYSE410 cells. When EC0156 cells were treated with paclitaxel, stathmin was stably phosphorylated and migration was impaired. These observations suggest that stathmin may have a more important function in ESCC development and migration. The present study provides further understanding of the importance of stathmin in ESCC therapy or diagnosis.

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