New Frontiers in Schistosoma Genomics and Transcriptomics

Overview

Journal J Parasitol Res

Publisher Wiley

Specialty Parasitology

Date 2012 Dec 11

PMID 23227308

Citations 7

Authors

Laila A Nahum

Marina M Mourao

Guilherme Oliveira

Affiliations

Soon will be listed here.

Abstract

Schistosomes are digenean blood flukes of aves and mammals comprising 23 species. Some species are causative agents of human schistosomiasis, the second major neglected disease affecting over 230 million people worldwide. Modern technologies including the sequencing and characterization of nucleic acids and proteins have allowed large-scale analyses of parasites and hosts, opening new frontiers in biological research with potential biomedical and biotechnological applications. Nuclear genomes of the three most socioeconomically important species (S. haematobium, S. japonicum, and S. mansoni) have been sequenced and are under intense investigation. Mitochondrial genomes of six Schistosoma species have also been completely sequenced and analysed from an evolutionary perspective. Furthermore, DNA barcoding of mitochondrial sequences is used for biodiversity assessment of schistosomes. Despite the efforts in the characterization of Schistosoma genomes and transcriptomes, many questions regarding the biology and evolution of this important taxon remain unanswered. This paper aims to discuss some advances in the schistosome research with emphasis on genomics and transcriptomics. It also aims to discuss the main challenges of the current research and to point out some future directions in schistosome studies.

Citing Articles

A Recent Advance in the Diagnosis, Treatment, and Vaccine Development for Human Schistosomiasis.

Chatterji T, Khanna N, Alghamdi S, Bhagat T, Gupta N, Alkurbi M Trop Med Infect Dis. 2024; 9(10).

PMID: 39453270 PMC: 11511416. DOI: 10.3390/tropicalmed9100243.

Schistosomiasis.

LoVerde P Adv Exp Med Biol. 2024; 1454:75-105.

PMID: 39008264 DOI: 10.1007/978-3-031-60121-7_3.

Adult Worm Protective and Diagnostic Proteins in -Butanol Extracts Revealed by Proteomic Analysis.

Sulbaran G, Verissimo da Costa G, Losada S, Peralta J, Cesari I Pathogens. 2022; 11(1).

PMID: 35055970 PMC: 8777762. DOI: 10.3390/pathogens11010022.

The Potential Role of Schistosome-Associated Factors as Therapeutic Modulators of the Immune System.

Li J, Liu H, Jiang J, She X, Niu Y, Ming Y Infect Immun. 2020; 88(8).

PMID: 32341115 PMC: 7375771. DOI: 10.1128/IAI.00754-19.

Crystal structure of a Schistosoma mansoni septin reveals the phenomenon of strand slippage in septins dependent on the nature of the bound nucleotide.

Zeraik A, Pereira H, Santos Y, Brandao-Neto J, Spoerner M, Santos M J Biol Chem. 2014; 289(11):7799-811.

PMID: 24464615 PMC: 3953292. DOI: 10.1074/jbc.M113.525352.

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