The Schistosoma Japonicum Genome Reveals Features of Host-parasite Interplay

Overview

Journal Nature

Specialty Science

Date 2009 Jul 17

PMID 19606140

Citations 333

Affiliations

Soon will be listed here.

Abstract

Schistosoma japonicum is a parasitic flatworm that causes human schistosomiasis, which is a significant cause of morbidity in China and the Philippines. Here we present a draft genomic sequence for the worm. The genome provides a global insight into the molecular architecture and host interaction of this complex metazoan pathogen, revealing that it can exploit host nutrients, neuroendocrine hormones and signalling pathways for growth, development and maturation. Having a complex nervous system and a well-developed sensory system, S. japonicum can accept stimulation of the corresponding ligands as a physiological response to different environments, such as fresh water or the tissues of its intermediate and mammalian hosts. Numerous proteases, including cercarial elastase, are implicated in mammalian skin penetration and haemoglobin degradation. The genomic information will serve as a valuable platform to facilitate development of new interventions for schistosomiasis control.

Citing Articles

Schistosoma sex-biased microRNAs regulate ovarian development and egg production by targeting Wnt signaling pathway.

Du P, Xia T, Li X, Giri B, Fang C, Li S Commun Biol. 2024; 7(1):1717.

PMID: 39741204 PMC: 11688426. DOI: 10.1038/s42003-024-07402-z.

Expression of Transposable Elements throughout the Trematode Life Cycle.

Skalon E, Panyushev N, Podgornaya O, Smolyaninova A, Solovyeva A Noncoding RNA. 2024; 10(4).

PMID: 39051373 PMC: 11270206. DOI: 10.3390/ncrna10040039.

Characterizing genetic variation on the Z chromosome in Schistosoma japonicum reveals host-parasite co-evolution.

Zhou A, Zhang W, Ge X, Liu Q, Luo F, Xu S Parasit Vectors. 2024; 17(1):207.

PMID: 38720339 PMC: 11080191. DOI: 10.1186/s13071-024-06250-4.

An inside out journey: biogenesis, ultrastructure and proteomic characterisation of the ectoparasitic flatworm Sparicotyle chrysophrii extracellular vesicles.

Riera-Ferrer E, Mazanec H, Mladineo I, Konik P, Piazzon M, Kuchta R Parasit Vectors. 2024; 17(1):175.

PMID: 38570784 PMC: 10993521. DOI: 10.1186/s13071-024-06257-x.

Prospects for genomic surveillance for selection in schistosome parasites.

Nikolakis Z, Adams R, Wade K, Lund A, Carlton E, Castoe T Front Epidemiol. 2024; 2:932021.

PMID: 38455290 PMC: 10910990. DOI: 10.3389/fepid.2022.932021.

References

Abouel-Nour M, Lotfy M, El-Kady I, El-Shahat M, Doughty B . Localization of leucine aminopeptidase in the Schistosoma mansoni eggs and in liver tissue from infected mice. J Egypt Soc Parasitol. 2005; 35(1):147-56. View

Putnam N, Srivastava M, Hellsten U, Dirks B, Chapman J, Salamov A . Sea anemone genome reveals ancestral eumetazoan gene repertoire and genomic organization. Science. 2007; 317(5834):86-94. DOI: 10.1126/science.1139158. View

Liu F, Lu J, Hu W, Wang S, Cui S, Chi M . New perspectives on host-parasite interplay by comparative transcriptomic and proteomic analyses of Schistosoma japonicum. PLoS Pathog. 2006; 2(4):e29. PMC: 1435792. DOI: 10.1371/journal.ppat.0020029. View

Hoffmann K, Davis E, Fischer E, Wynn T . The guanine protein coupled receptor rhodopsin is developmentally regulated in the free-living stages of Schistosoma mansoni. Mol Biochem Parasitol. 2001; 112(1):113-23. DOI: 10.1016/s0166-6851(00)00352-2. View

Foster J, Mercer J, Rees H . Analysis of ecdysteroids in the trematodes, Schistosoma mansoni and Fasciola hepatica. Trop Med Parasitol. 1992; 43(4):239-44. View

Kumar S, Tamura K, Nei M . MEGA3: Integrated software for Molecular Evolutionary Genetics Analysis and sequence alignment. Brief Bioinform. 2004; 5(2):150-63. DOI: 10.1093/bib/5.2.150. View

ADAMSON P . Schistosomiasis in antiquity. Med Hist. 1976; 20(2):176-88. PMC: 1081737. DOI: 10.1017/s0025727300022237. View

Mousley A, Maule A, Halton D, Marks N . Inter-phyla studies on neuropeptides: the potential for broad-spectrum anthelmintic and/or endectocide discovery. Parasitology. 2006; 131 Suppl:S143-67. DOI: 10.1017/S0031182005008553. View

Dvorak J, Delcroix M, Rossi A, Vopalensky V, Pospisek M, Sedinova M . Multiple cathepsin B isoforms in schistosomula of Trichobilharzia regenti: identification, characterisation and putative role in migration and nutrition. Int J Parasitol. 2005; 35(8):895-910. DOI: 10.1016/j.ijpara.2005.02.018. View

10.

Dvorak J, Mashiyama S, Braschi S, Sajid M, Knudsen G, Hansell E . Differential use of protease families for invasion by schistosome cercariae. Biochimie. 2007; 90(2):345-58. DOI: 10.1016/j.biochi.2007.08.013. View

11.

Curwen R, Ashton P, Sundaralingam S, Wilson R . Identification of novel proteases and immunomodulators in the secretions of schistosome cercariae that facilitate host entry. Mol Cell Proteomics. 2006; 5(5):835-44. DOI: 10.1074/mcp.M500313-MCP200. View

12.

Xu Y, Shawar S, Dresden M . Schistosoma mansoni: purification and characterization of a membrane-associated leucine aminopeptidase. Exp Parasitol. 1990; 70(2):124-33. DOI: 10.1016/0014-4894(90)90093-r. View

13.

Brejova B, Vinar T, Chen Y, Wang S, Zhao G, Brown D . Finding genes in Schistosoma japonicum: annotating novel genomes with help of extrinsic evidence. Nucleic Acids Res. 2009; 37(7):e52. PMC: 2673418. DOI: 10.1093/nar/gkp052. View

14.

Mullikin J, Ning Z . The phusion assembler. Genome Res. 2003; 13(1):81-90. PMC: 430959. DOI: 10.1101/gr.731003. View

15.

Wei C, Ng P, Chiu K, Wong C, Ang C, Lipovich L . 5' Long serial analysis of gene expression (LongSAGE) and 3' LongSAGE for transcriptome characterization and genome annotation. Proc Natl Acad Sci U S A. 2004; 101(32):11701-6. PMC: 511040. DOI: 10.1073/pnas.0403514101. View

16.

Newport G, McKerrow J, Hedstrom R, Petitt M, McGarrigle L, Barr P . Cloning of the proteinase that facilitates infection by schistosome parasites. J Biol Chem. 1988; 263(26):13179-84. View

17.

Hirai H, Taguchi T, Saitoh Y, Kawanaka M, Sugiyama H, Habe S . Chromosomal differentiation of the Schistosoma japonicum complex. Int J Parasitol. 2000; 30(4):441-52. DOI: 10.1016/s0020-7519(99)00186-1. View

18.

Koehler J, Morales M, Shelby B, Brindley P . Aspartic protease activities of schistosomes cleave mammalian hemoglobins in a host-specific manner. Mem Inst Oswaldo Cruz. 2007; 102(1):83-5. DOI: 10.1590/s0074-02762007000100014. View

19.

Smart D, Johnston C, Curry W, Williamson R, Maule A, Skuce P . Peptides related to the Diploptera punctata allatostatins in nonarthropod invertebrates: an immunocytochemical survey. J Comp Neurol. 1994; 347(3):426-32. DOI: 10.1002/cne.903470308. View

20.

. The universal protein resource (UniProt). Nucleic Acids Res. 2007; 36(Database issue):D190-5. PMC: 2238893. DOI: 10.1093/nar/gkm895. View