Snapshots: Chromatin Control of Viral Infection

Overview

Journal Virology

Specialty Microbiology

Date 2012 Dec 11

PMID 23217624

Citations 102

Authors

David M Knipe

Paul M Lieberman

Jae U Jung

Alison A McBride

Kevin V Morris

Melanie Ott

David Margolis

Amelia Nieto

Michael Nevels

Robin J Parks

Thomas M Kristie

Affiliations

Soon will be listed here.

Abstract

Like their cellular host counterparts, many invading viral pathogens must contend with, modulate, and utilize the host cell's chromatin machinery to promote efficient lytic infection or control persistent-latent states. While not intended to be comprehensive, this review represents a compilation of conceptual snapshots of the dynamic interplay of viruses with the chromatin environment. Contributions focus on chromatin dynamics during infection, viral circumvention of cellular chromatin repression, chromatin organization of large DNA viruses, tethering and persistence, viral interactions with cellular chromatin modulation machinery, and control of viral latency-reactivation cycles.

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