NK Cells Controlling Virus-specific T Cells: Rheostats for Acute Vs. Persistent Infections

Overview

Journal Virology

Specialty Microbiology

Date 2012 Dec 11

PMID 23217614

Citations 53

Authors

Raymond M Welsh

Stephen N Waggoner

Affiliations

Soon will be listed here.

Abstract

Viral infections characteristically induce a cytokine-driven activated natural killer (NK) cell response that precedes an antigen-driven T cell response. These NK cells can restrain some but not all viral infections by attacking virus-infected cells and can thereby provide time for an effective T cell response to mobilize. Recent studies have revealed an additional immunoregulatory role for the NK cells, where they inhibit the size and functionality of the T cell response, regardless of whether the viruses are themselves sensitive to NK cells. This subsequent change in T cell dynamics can alter patterns of immunopathology and persistence and implicates NK cells as rheostat-like regulators of persistent infections.

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