Control of HCV Infection by Natural Killer Cells and Macrophages

Overview

Journal Cold Spring Harb Perspect Med

Specialty General Medicine

Date 2019 Dec 25

PMID 31871225

Citations 9

Authors

Hugo R Rosen

Lucy Golden-Mason

Affiliations

Soon will be listed here.

Abstract

Host defense against invading pathogens within the liver is dominated by innate immunity. Natural killer (NK) cells have been implicated at all stages of hepatitis C virus (HCV) infection, from providing innate protection to contributing to treatment-induced clearance. Decreased NK cell levels, altered NK cell subset distribution, activation marker expression, and functional polarization toward a cytolytic phenotype are hallmarks of chronic HCV infection. Interferon α (IFN-α) is a potent activator of NK cells; therefore, it is not surprising that NK cell activation has been identified as a key factor associated with sustained virological response (SVR) to IFN-α-based therapies. Understanding the role of NK cells, macrophages, and other innate immune cells post-SVR remains paramount for prevention of disease pathogenesis and progression. Novel strategies to treat liver disease may be aimed at targeting these cells.

Citing Articles

Contemporary Insights into Hepatitis C Virus: A Comprehensive Review.

Sallam M, Khalil R Microorganisms. 2024; 12(6).

PMID: 38930417 PMC: 11205832. DOI: 10.3390/microorganisms12061035.

Unmet needs in the post-direct-acting antivirals era: The risk and molecular mechanisms of hepatocellular carcinoma after hepatitis C virus eradication.

Huang C, Awad M, Gal-Tanamy M, Yu M Clin Mol Hepatol. 2024; 30(3):326-344.

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Unraveling the role of the liver myeloid compartment during hepatitis C virus cure.

Crouchet E, Baumert T J Hepatol. 2023; 80(2):184-187.

PMID: 37088307 PMC: 7615597. DOI: 10.1016/j.jhep.2023.04.016.

Etiology of end-stage liver cirrhosis impacts hepatic natural killer cell heterogenicity.

Maretti-Mira A, Salomon M, Hsu A, Dara L, Golden-Mason L Front Immunol. 2023; 14:1137034.

PMID: 37063898 PMC: 10098346. DOI: 10.3389/fimmu.2023.1137034.

Galectin-9 and Interferon-Gamma Are Released by Natural Killer Cells upon Activation with Interferon-Alpha and Orchestrate the Suppression of Hepatitis C Virus Infection.

Carreca A, Gaetani M, Busa R, Francipane M, Gulotta M, Perricone U Viruses. 2022; 14(7).

PMID: 35891518 PMC: 9317111. DOI: 10.3390/v14071538.

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