Painting Proteins Blue: β-(1-azulenyl)-L-alanine As a Probe for Studying Protein-protein Interactions

Overview

Journal Chem Commun (Camb)

Publisher Royal Society of Chemistry

Specialty Chemistry

Date 2012 Dec 5

PMID 23207368

Citations 24

Authors

Yurii S Moroz

Wolfgang Binder

Patrik Nygren

Gregory A Caputo

Ivan V Korendovych

Affiliations

Soon will be listed here.

Abstract

We demonstrated that β-(1-azulenyl)-L-alanine, a fluorescent pseudoisosteric analog of tryptophan, exhibits weak environmental dependence and thus allows for using weak intrinsic quenchers, such as methionines, to monitor protein-protein interactions while not perturbing them.

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