Regulation and Control of Myosin-I by the Motor and Light Chain-binding Domains

Overview

Journal Trends Cell Biol

Specialty Cell Biology

Date 2012 Dec 4

PMID 23200340

Citations 36

Authors

Michael J Greenberg

E Michael Ostap

Affiliations

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Abstract

Members of the myosin-I family of molecular motors are expressed in many eukaryotes, where they are involved in a multitude of critical processes. Humans express eight distinct members of the myosin-I family, making it the second largest family of myosins expressed in humans. Despite the high degree of sequence conservation in the motor and light chain-binding domains (LCBDs) of these myosins, recent studies have revealed surprising diversity of function and regulation arising from isoform-specific differences in these domains. Here we review the regulation of myosin-I function and localization by the motor and LCBDs.

Citing Articles

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