Genome-wide Sequencing to Identify the Cause of Hereditary Cancer Syndromes: with Examples from Familial Pancreatic Cancer

Overview

Journal Cancer Lett

Specialty Oncology

Date 2012 Dec 1

PMID 23196058

Citations 13

Authors

Nicholas J Roberts

Alison P Klein

Affiliations

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Abstract

Advances in our understanding of the human genome and next-generation technologies have facilitated the use of genome-wide sequencing to decipher the genetic basis of Mendelian disease and hereditary cancer syndromes. However, the application of genome-wide sequencing in hereditary cancer syndromes has had mixed success, in part, due to complex nature of the underlying genetic architecture. In this review we discuss the use of genome-wide sequencing in both Mendelian diseases and hereditary cancer syndromes, highlighting the potential and challenges of this approach using familial pancreatic cancer as an example.

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