Is Gender Influencing the Biomechanical Results After Autologous Chondrocyte Implantation?

Overview

Journal Knee Surg Sports Traumatol Arthrosc

Publisher Wiley

Specialties Emergency Medicine
General Surgery
Orthopedics

Date 2012 Nov 29

PMID 23188497

Citations 10

Authors

Peter C Kreuz

Sebastian Muller

Christoph Erggelet

Arvind von Keudell

Thomas Tischer

Christian Kaps

Philipp Niemeyer

Anja Hirschmuller

Affiliations

Soon will be listed here.

Abstract

Purpose: The influence of gender on the biomechanical outcome after autologous chondrocyte implantation (ACI) including isokinetic muscle strength measurements has not been investigated. The present prospective study was performed to evaluate gender-specific differences in the biomechanical function 48 months after ACI.

Methods: Fifty-two patients (mean age 35.6 ± 8.5 years) that met our inclusion criteria, underwent ACI with Bioseed C(®) and were evaluated with the KOOS score preoperatively, 6, 12 and 48 months after surgery. At final follow-up, 44 out of the 52 patients underwent biomechanical evaluation with isokinetic strength measurements of both knees. All data were evaluated separately for men and women and compared for each time interval using the Mann-Whitney U test.

Results: Clinical scores improved significantly over the whole study period (p < 0.05). Male patients demonstrated significantly better scores during the follow-up in the KOOS score (p < 0.05). Isokinetic strength measurements after 48 months revealed a significant strength deficit of the treated knee in all test modes compared to the healthy extremity (p < 0.05). Furthermore, male patients achieved significantly higher strength values compared to female patients (p < 0.05).

Conclusions: ACI is a viable treatment option for full-thickness chondral defects in the knee of both genders. Isokinetic muscle strength measures are significantly worse in women (p < 0.05), but physiological and may play a role for the explanation of gender-specific results after ACI.

Citing Articles

Increased risk of reoperation and failure to attain clinically relevant improvement following autologous chondrocyte implantation of the knee in female patients and individuals with previous surgeries: a time-to-event analysis based on the German....

Bumberger A, Rupp M, Lattermann C, Kleiner A, Niemeyer P Knee Surg Sports Traumatol Arthrosc. 2023; 31(12):5837-5847.

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Stem Cells for Cartilage Repair: Preclinical Studies and Insights in Translational Animal Models and Outcome Measures.

Lo Monaco M, Merckx G, Ratajczak J, Gervois P, Hilkens P, Clegg P Stem Cells Int. 2018; 2018:9079538.

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Quadriceps Strength in Patients With Isolated Cartilage Defects of the Knee: Results of Isokinetic Strength Measurements and Their Correlation With Clinical and Functional Results.

Hirschmuller A, Andres T, Schoch W, Baur H, Konstantinidis L, Sudkamp N Orthop J Sports Med. 2017; 5(5):2325967117703726.

PMID: 28596973 PMC: 5448737. DOI: 10.1177/2325967117703726.

Development of a Tool to Predict Outcome of Autologous Chondrocyte Implantation.

Dugard M, Kuiper J, Parker J, Roberts S, Robinson E, Harrison P Cartilage. 2017; 8(2):119-130.

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Incomplete defect filling after third generation autologous chondrocyte implantation.

Niethammer T, Pietschmann M, Ficklscherer A, Gulecyuz M, Hammerschmid F, Muller P Arch Med Sci. 2016; 12(4):785-92.

PMID: 27478460 PMC: 4947626. DOI: 10.5114/aoms.2016.60967.

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