» Articles » PMID: 24441734

Microfracture Technique Versus Osteochondral Autologous Transplantation Mosaicplasty in Patients with Articular Chondral Lesions of the Knee: a Prospective Randomized Trial with Long-term Follow-up

Overview
Publisher Wiley
Date 2014 Jan 21
PMID 24441734
Citations 49
Authors
Affiliations
Soon will be listed here.
Abstract

Purpose: To compare long-term functional and radiological outcome following microfracture technique (MF) versus osteochondral autologous transplantation (OAT) mosaicplasty for treating focal chondral lesions of the knee.

Methods: Twenty-five patients (mean age 32.3 years, SD 7.7) with a full-thickness (International Cartilage Repair Society grade 3 or 4) chondral lesion of the articulating surface of the femur were randomized to either MF (n = 11) or OAT mosaicplasty (n = 14). At a median follow-up of 9.8 years (range 4.9-11.4), the patients were evaluated using Lysholm score (n = 25), Knee Injury and Osteoarthritis Outcome Score (KOOS, n = 25), isokinetic quadriceps measurement and hamstring strength measurement (n = 22) and standing radiographs (n = 23).

Results: There were no significant differences in Lysholm score, KOOS, isokinetic muscle strength or radiographic osteoarthritis between MF-treated patients and OAT mosaicplasty-treated patients at follow-up. Mean Lysholm score at follow-up was 69.7 [95% confidence interval (CI), 55.1-84.4] for the MF group and 62.6 (95% CI, 52.6-72.6) for the OAT mosaicplasty group.

Conclusion: At long-term follow-up, there were no significant differences between patients treated with MF and patients treated with OAT mosaicplasty in patient-reported outcomes, muscle strength or radiological outcome.

Level Of Evidence: Therapeutic study, Level II.

Citing Articles

A prospective randomized controlled trial comparing biphasic cartilage repair implant with microfracture in small chondral lesions of knee: findings at five-year-follow-up.

Kuo Y, Chiu S, Chang W, Chen C, Chen C, Liaw C J Orthop Surg Res. 2025; 20(1):73.

PMID: 39833829 PMC: 11745012. DOI: 10.1186/s13018-024-05392-6.


Comparison of the bioactivity and apoptotic responses of hyaline cartilage chondrocytes and fibrocartilage chondrocytes obtained by bone marrow stimulation in rats.

Cicek H, Tuhanioglu U, Cicek F Acta Orthop Traumatol Turc. 2024; 58(5):250-254.

PMID: 39560637 PMC: 11583943. DOI: 10.5152/j.aott.2024.22172.


Acellular Aragonite-Based Scaffold for the Treatment of Joint Surface Lesions of the Knee: A Minimum 5-Year Follow-Up Study.

De Caro F, Vuylsteke K, Van Genechten W, Verdonk P Cartilage. 2024; 15(4):399-406.

PMID: 38899593 PMC: 11520016. DOI: 10.1177/19476035241227346.


Does progress in microfracture techniques necessarily translate into clinical effectiveness?.

Muthu S, Viswanathan V, Sakthivel M, Thabrez M World J Orthop. 2024; 15(3):266-284.

PMID: 38596189 PMC: 10999967. DOI: 10.5312/wjo.v15.i3.266.


10-Year Prospective Clinical and Radiological Evaluation After Matrix-Induced Autologous Chondrocyte Implantation and Comparison of Tibiofemoral and Patellofemoral Graft Outcomes.

Ebert J, Zheng M, Fallon M, Wood D, Janes G Am J Sports Med. 2024; 52(4):977-986.

PMID: 38384192 PMC: 10943616. DOI: 10.1177/03635465241227969.


References
1.
Frisbie D, Oxford J, Southwood L, Trotter G, Rodkey W, Steadman J . Early events in cartilage repair after subchondral bone microfracture. Clin Orthop Relat Res. 2003; (407):215-27. DOI: 10.1097/00003086-200302000-00031. View

2.
Solheim E, Hegna J, Oyen J, Harlem T, Strand T . Results at 10 to 14 years after osteochondral autografting (mosaicplasty) in articular cartilage defects in the knee. Knee. 2013; 20(4):287-90. DOI: 10.1016/j.knee.2013.01.001. View

3.
Chow J, Hantes M, Houle J, Zalavras C . Arthroscopic autogenous osteochondral transplantation for treating knee cartilage defects: a 2- to 5-year follow-up study. Arthroscopy. 2004; 20(7):681-90. DOI: 10.1016/j.arthro.2004.06.005. View

4.
Gudas R, Stankevicius E, Monastyreckiene E, Pranys D, Kalesinskas R . Osteochondral autologous transplantation versus microfracture for the treatment of articular cartilage defects in the knee joint in athletes. Knee Surg Sports Traumatol Arthrosc. 2006; 14(9):834-42. DOI: 10.1007/s00167-006-0067-0. View

5.
Hangody L, Dobos J, Balo E, Panics G, Hangody L, Berkes I . Clinical experiences with autologous osteochondral mosaicplasty in an athletic population: a 17-year prospective multicenter study. Am J Sports Med. 2010; 38(6):1125-33. DOI: 10.1177/0363546509360405. View