In Vitro Experimental Investigation of Voice Production
Overview
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The process of human phonation involves a complex interaction between the physical domains of structural dynamics, fluid flow, and acoustic sound production and radiation. Given the high degree of nonlinearity of these processes, even small anatomical or physiological disturbances can significantly affect the voice signal. In the worst cases, patients can lose their voice and hence the normal mode of speech communication. To improve medical therapies and surgical techniques it is very important to understand better the physics of the human phonation process. Due to the limited experimental access to the human larynx, alternative strategies, including artificial vocal folds, have been developed. The following review gives an overview of experimental investigations of artificial vocal folds within the last 30 years. The models are sorted into three groups: static models, externally driven models, and self-oscillating models. The focus is on the different models of the human vocal folds and on the ways in which they have been applied.
Synthetic, self-oscillating vocal fold models for voice production researcha).
Thomson S J Acoust Soc Am. 2024; 156(2):1283-1308.
PMID: 39172710 PMC: 11348498. DOI: 10.1121/10.0028267.
Three-Dimensional Printing of Ultrasoft Silicone with a Functional Stiffness Gradient.
Young C, OBannon M, Thomson S 3D Print Addit Manuf. 2024; 11(2):435-445.
PMID: 38689918 PMC: 11057526. DOI: 10.1089/3dp.2022.0218.
Drug delivery systems for wound healing treatment of upper airway injury.
Cruz D, Zheng A, Debele T, Larson P, Dion G, Park Y Expert Opin Drug Deliv. 2024; 21(4):573-591.
PMID: 38588553 PMC: 11208077. DOI: 10.1080/17425247.2024.2340653.
Flow-induced oscillations of vocal-fold replicas with tuned extensibility and material properties.
Luizard P, Bailly L, Yousefi-Mashouf H, Girault R, Orgeas L, Henrich Bernardoni N Sci Rep. 2023; 13(1):22658.
PMID: 38114547 PMC: 10730560. DOI: 10.1038/s41598-023-48080-x.
Dollinger M, Jakubass B, Cheng H, Carter S, Kniesburges S, Aidoo B Laryngoscope Investig Otolaryngol. 2023; 8(5):1294-1303.
PMID: 37899858 PMC: 10601582. DOI: 10.1002/lio2.1140.