Polymorphisms in ERCC1 and XPF Genes and Risk of Gastric Cancer in an Eastern Chinese Population

Overview

Journal PLoS One

Specialties General Medicine
Science

Date 2012 Nov 21

PMID 23166636

Citations 26

Authors

Jing He

Yu Xu

Li-Xin Qiu

Jin Li

Xiao-yan Zhou

Meng-Hong Sun

Jiu-Cun Wang

Ya-Jun Yang

Li Jin

Qing-Yi Wei

Yanong Wang

Affiliations

Soon will be listed here.

Abstract

Background: Inherited functional single nucleotide polymorphisms (SNPs) in DNA repair genes may alter DNA repair capacity and thus contribute to cancer risk.

Methods: Three ERCC1 functional SNPs (rs2298881C>A, rs3212986C>A and rs11615G>A) and two XPF/ERCC4 functional SNPs (rs2276466C>G and rs6498486A>C) were genotyped for 1125 gastric adenocarcinoma cases and 1196 cancer-free controls by Taqman assays. Odds ratios (OR) and 95% confidence intervals (CI) were used to estimate risk associations, and false-positive report probabilities (FPRP) were calculated for assessing significant findings.

Results: ERCC1 rs2298881C and rs11615A variant genotypes were associated with increased gastric cancer risk (adjusted OR=1.33, 95% CI=1.05-1.67 for rs2298881 AC/CC and adjusted OR=1.23, 95% CI=1.05-1.46 for rs11615 AG/AA, compared with their common genotype AA and GG, respectively). Patients with 2-3 ERCC1 risk genotypes had significant increased risk (adjusted OR=1.56, 95% CI=1.27-1.93), compared with those with 0-1 ERCC1 risk genotypes, and this risk was more significantly in subgroups of never drinkers, non-gastric cardia adenocarcinoma (NGCA) and clinical stage I+II. All these risks were not observed for XPF SNPs.

Conclusions: These findings suggest that functional ERCC1 SNPs may contribute to risk of gastric cancer. Larger and well-designed studies with different ethnic populations are needed to validate our findings.

Citing Articles

Genetic Variations in Nucleotide Excision Repair Pathway Genes and Risk of Allergic Rhinitis.

Liu W, Zeng Q, Zeng Y, Tang Y, Luo R Mediators Inflamm. 2022; 2022:7815283.

PMID: 35693108 PMC: 9187482. DOI: 10.1155/2022/7815283.

The link of ERCC2 rs13181 and ERCC4 rs2276466 polymorphisms with breast cancer in the Bangladeshi population.

Sahaba S, Rashid M, Islam M, Nahid N, Apu M, Sultana T Mol Biol Rep. 2021; 49(3):1847-1856.

PMID: 34837148 DOI: 10.1007/s11033-021-06994-7.

Distribution and susceptibility of ERCC1/XPF gene polymorphisms in Han and Uygur women with breast cancer in Xinjiang, China.

Li H, Zhou L, Ma J, Zhu Y, Fan J, Li N Cancer Med. 2020; 9(24):9571-9580.

PMID: 33067872 PMC: 7774751. DOI: 10.1002/cam4.3547.

Impact of XPF rs2276466 polymorphism on cancer susceptibility: a meta-analysis.

Liu Y, Liu K, Zhao X, Sun Y, Ma N, Tang L Biosci Rep. 2019; 39(5).

PMID: 31040199 PMC: 6533207. DOI: 10.1042/BSR20181785.

Function and Interactions of ERCC1-XPF in DNA Damage Response.

Faridounnia M, Folkers G, Boelens R Molecules. 2018; 23(12).

PMID: 30563071 PMC: 6320978. DOI: 10.3390/molecules23123205.

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