A Genome-wide Association Study Identifies New Susceptibility Loci for Non-cardia Gastric Cancer at 3q13.31 and 5p13.1

Overview

Journal Nat Genet

Specialty Genetics

Date 2011 Nov 1

PMID 22037551

Citations 157

Authors

Yongyong Shi

Zhibin Hu

Chen Wu

Juncheng Dai

Huizhang Li

Jing Dong

Meilin Wang

Xiaoping Miao

Yifeng Zhou

Feng Lu

Hanze Zhang

Lingmin Hu

Yue Jiang

Zhiqiang Li

Minjie Chu

Hongxia Ma

Jiaping Chen

Guangfu Jin

Wen Tan

Tangchun Wu

Zhengdong Zhang

Dongxin Lin

Hongbing Shen

Affiliations

Soon will be listed here.

Abstract

Gastric cancer, including the cardia and non-cardia types, is the second leading cause of cancer-related deaths worldwide. To identify genetic risk variants for non-cardia gastric cancer, we performed a genome-wide association study in 3,279 individuals (1,006 with non-cardia gastric cancer and 2,273 controls) of Chinese descent. We replicated significant associations in an additional 6,897 subjects (3,288 with non-cardia gastric cancer and 3,609 controls). We identified two new susceptibility loci for non-cardia gastric cancer at 5p13.1 (rs13361707 in the region including PTGER4 and PRKAA1; odds ratio (OR) = 1.41; P = 7.6 × 10(-29)) and 3q13.31 (rs9841504 in ZBTB20; OR = 0.76; P = 1.7 × 10(-9)). Imputation analyses also confirmed previously reported associations of rs2294008 and rs2976392 on 8q24, rs4072037 on 1q22 and rs13042395 on 20p13 with non-cardia gastric cancer susceptibility in the Han Chinese population.

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