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Monoclonal Antibody HML-1, a Marker for Intraepithelial T Cells and Lymphomas Derived Thereof, Also Recognizes Hairy Cell Leukemia and Some B-cell Lymphomas

Overview
Journal Am J Pathol
Publisher Elsevier
Specialty Pathology
Date 1990 Mar 1
PMID 2316623
Citations 9
Authors
P Moller
B Mielke
G Moldenhauer
Affiliations
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Abstract

Current views regard monoclonal antibody HML-1 as an exquisite marker for intraepithelial T cells and primary intestinal and cutaneous T-cell lymphomas. We show that HML-1 reacted with 11 of 12 cases of hairy cell leukemia, with 1 of 13 cases of primary gastrointestinal B-cell lymphoma, and with an unclassified large-cell B lymphoma of the thoracic wall. We conclude that HML-1 is not restricted to the T-cell lineage and that the HML-1 antigen is expressed in a small subset of both T- and B-cell neoplasms.

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