HML-1 Antigen on Mucosa-associated T Cells, Activated Cells, and Hairy Leukemic Cells is a New Integrin Containing the Beta 7 Subunit

Overview

Journal Am J Pathol

Publisher Elsevier

Specialty Pathology

Date 1991 Dec 1

PMID 1750505

Citations 12

Authors

K J Micklem

Y Dong

A Willis

K A Pulford

L Visser

H Durkop

S Poppema

H STEIN

D Y Mason

Affiliations

Soon will be listed here.

Abstract

The monoclonal antibodies HML-1, B-ly7 and Ber-ACT8 recognize intramucosal gut T lymphocytes, activated cells, and hairy cell leukemia. The antigen on hairy cells consists of three glycoproteins (160 kappa D, 130 kappa D and 105 kappa D unreduced; 145 kappa D and 120 kappa D reduced). These peptides have biochemical features reminiscent of integrins but we have shown by immunoprecipitation that they are not known integrin subunits. We have used a newly produced antibody (BP6) to purify this molecule and shown by N-terminal sequence analysis that the smallest subunit is the product of integrin beta 7 cDNA. This molecule is thus a new member of the integrin family of leucocyte adhesion proteins. Immunoprecipitation experiments indicate that the two larger subunits are recognized by HML-1, B-ly7 and Ber-ACT8.

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